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RTCA

GENERAL INFORMATION

Gene name

 RTCA

Gene description

 RNA 3'-terminal phosphate cyclase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA027982 , HPA028151
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RTCA (HGNC Symbol)

Synonyms

 RPC, RTC1, RTCD1

Description

 RNA 3'-terminal phosphate cyclase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 1

Cytoband

 p21.2

Chromosome location (bp)

 100266207 - 100292769

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137996 (version 83.38)

Entrez gene

 8634

UniProt

 O00442 (UniProt - Evidence at protein level)

neXtProt

 NX_O00442

Antibodypedia

 RTCA antibodies

PROTEIN BROWSER
RTCA-001
RTCA-002
RTCA-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RTCA-001
ENSP00000359146
ENST00000370128
O00442 [Direct mapping]
RNA 3'-terminal phosphate cyclase
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0003963 [RNA-3'-phosphate cyclase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006396 [RNA processing]
GO:0044822 [poly(A) RNA binding]
Show all
 366 aa
39.3 kDa 		No 0
RTCA-002
ENSP00000260563
ENST00000260563
O00442 [Direct mapping]
RNA 3'-terminal phosphate cyclase
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0003963 [RNA-3'-phosphate cyclase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006396 [RNA processing]
GO:0044822 [poly(A) RNA binding]
Show all
 379 aa
40.7 kDa 		No 0
RTCA-003
ENSP00000359144
ENST00000370126
A6NIC1 [Direct mapping]
RNA 3'-terminal phosphate cyclase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0006396 [RNA processing]
Show all
 49 aa
5.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.