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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADCY3
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADCY3

Gene description

Adenylate cyclase 3

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB010223
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB010223

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Prostate cancers demonstrated strong cytoplasmic immunoreactivity, while several cases of endometrial, renal and gastric cancers showed moderate immunoreactivity. Remaining cancers were in general weakly stained or negative.

GENE INFORMATION

Gene name

ADCY3 (HGNC Symbol)

Synonyms

AC3

Description

Adenylate cyclase 3 (HGNC Symbol)

Entrez gene summary

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p23.3

Chromosome location (bp)

24819169 - 24919839

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138031 (version 83.38)

Entrez gene

109

UniProt

O60266 (UniProt - Evidence at protein level)

neXtProt

NX_O60266

Antibodypedia

ADCY3 antibodies

PROTEIN BROWSER

ADCY3-001
ADCY3-002
ADCY3-003
ADCY3-004
ADCY3-006
ADCY3-009
ADCY3-010
ADCY3-013
ADCY3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADCY3-001
ENSP00000260600
ENST00000260600
O60266 [Direct mapping]
Adenylate cyclase type 3
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0004016 [adenylate cyclase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005929 [cilium]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007143 [female meiotic division]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007338 [single fertilization]
GO:0007340 [acrosome reaction]
GO:0007608 [sensory perception of smell]
GO:0008294 [calcium- and calmodulin-responsive adenylate cyclase activity]
GO:0008355 [olfactory learning]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0019933 [cAMP-mediated signaling]
GO:0030317 [sperm motility]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0055085 [transmembrane transport]
GO:0071377 [cellular response to glucagon stimulus]
GO:1904322 [cellular response to forskolin]
Show all
1144 aa
129 kDa
No >9
ADCY3-002
ENSP00000389799
ENST00000435135
C9JLX3 [Direct mapping]
Adenylate cyclase type 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005622 [intracellular]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
482 aa
53.6 kDa
No 4
ADCY3-003
ENSP00000401455
ENST00000433852
C9JYB5 [Direct mapping]
Adenylate cyclase type 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
155 aa
18 kDa
No 1
ADCY3-004
ENSP00000406153
ENST00000438445
C9J969 [Direct mapping]
Adenylate cyclase type 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
112 aa
12.6 kDa
No 1
ADCY3-006
ENSP00000475652
ENST00000606682
U3KQ91 [Direct mapping]
Adenylate cyclase type 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005622 [intracellular]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
791 aa
89.1 kDa
No 5
ADCY3-009
ENSP00000476143
ENST00000498288
U3KQR1 [Direct mapping]
Adenylate cyclase type 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
49 aa
5.5 kDa
No 0
ADCY3-010
ENSP00000399275
ENST00000427849
H7C1A6 [Direct mapping]
Adenylate cyclase type 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005622 [intracellular]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
298 aa
33 kDa
No 0
ADCY3-013
ENSP00000402008
ENST00000455323
H7C1S5 [Direct mapping]
Adenylate cyclase type 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
198 aa
22.5 kDa
No 5
ADCY3-201
ENSP00000384484
ENST00000405392
A0A0A0MSC1 [Direct mapping]
Adenylate cyclase type 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004016 [adenylate cyclase activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
1145 aa
129 kDa
No >9

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The Human Protein Atlas project is funded
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