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PPM1B

GENERAL INFORMATION

Gene name

 PPM1B

Gene description

 Protein phosphatase, Mg2+/Mn2+ dependent, 1B

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA016745
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016745

GENE INFORMATION

Gene name

 PPM1B (HGNC Symbol)

Synonyms

 PP2CB, PP2CBETA, PPC2BETAX

Description

 Protein phosphatase, Mg2+/Mn2+ dependent, 1B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p21

Chromosome location (bp)

 44167969 - 44244384

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138032 (version 83.38)

Entrez gene

 5495

UniProt

 O75688 (UniProt - Evidence at protein level)

neXtProt

 NX_O75688

Antibodypedia

 PPM1B antibodies

PROTEIN BROWSER
PPM1B-001
PPM1B-002
PPM1B-003
PPM1B-004
PPM1B-005
PPM1B-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPM1B-001
ENSP00000282412
ENST00000282412
O75688 [Direct mapping]
Protein phosphatase 1B
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006499 [N-terminal protein myristoylation]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030145 [manganese ion binding]
GO:0032688 [negative regulation of interferon-beta production]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043169 [cation binding]
GO:0050687 [negative regulation of defense response to virus]
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 479 aa
52.6 kDa 		No 0
PPM1B-002
ENSP00000367813
ENST00000378551
O75688 [Direct mapping]
Protein phosphatase 1B
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006499 [N-terminal protein myristoylation]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030145 [manganese ion binding]
GO:0032688 [negative regulation of interferon-beta production]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043169 [cation binding]
GO:0050687 [negative regulation of defense response to virus]
Show all
 387 aa
42.8 kDa 		No 0
PPM1B-003
ENSP00000326089
ENST00000345249
O75688 [Direct mapping]
Protein phosphatase 1B
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006499 [N-terminal protein myristoylation]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030145 [manganese ion binding]
GO:0032688 [negative regulation of interferon-beta production]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0050687 [negative regulation of defense response to virus]
Show all
 192 aa
20.8 kDa 		No 0
PPM1B-004
ENSP00000387287
ENST00000409432
O75688 [Direct mapping]
Protein phosphatase 1B
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006499 [N-terminal protein myristoylation]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030145 [manganese ion binding]
GO:0032688 [negative regulation of interferon-beta production]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043169 [cation binding]
GO:0050687 [negative regulation of defense response to virus]
Show all
 380 aa
42.1 kDa 		No 0
PPM1B-005
ENSP00000390087
ENST00000419807
C9JIR6 [Direct mapping]
Protein phosphatase 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0030145 [manganese ion binding]
GO:0043169 [cation binding]
Show all
 378 aa
41.8 kDa 		No 0
PPM1B-011
ENSP00000386982
ENST00000409473
B8ZZF0 [Direct mapping]
Protein phosphatase 1B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0030145 [manganese ion binding]
GO:0043169 [cation binding]
Show all
 303 aa
33.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.