Expression of SLC5A6 in cancer - Summary - The Human Protein Atlas

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SLC5A6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC5A6
Gene description	Solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036958
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036958

GENE INFORMATION
Gene name	SLC5A6 (HGNC Symbol)
Synonyms	SMVT
Description	Solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	27199587 - 27212958
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138074 (version 83.38)
Entrez gene	8884
UniProt	Q9Y289 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y289
Antibodypedia	SLC5A6 antibodies

PROTEIN BROWSER

SLC5A6-001	SLC5A6-003	SLC5A6-004	SLC5A6-005	SLC5A6-006	SLC5A6-007	SLC5A6-009	SLC5A6-010	SLC5A6-011	SLC5A6-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC5A6-001 ENSP00000310208 ENST00000310574	Q9Y289 [Direct mapping] Sodium-dependent multivitamin transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006768 [biotin metabolic process] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0008523 [sodium-dependent multivitamin transmembrane transporter activity] GO:0012506 [vesicle membrane] GO:0015878 [biotin transport] GO:0015887 [pantothenate transmembrane transport] GO:0015939 [pantothenate metabolic process] GO:0016020 [membrane] GO:0031526 [brush border membrane] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	635 aa 68.6 kDa	No	>9
SLC5A6-003 ENSP00000384853 ENST00000408041	Q9Y289 [Direct mapping] Sodium-dependent multivitamin transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006768 [biotin metabolic process] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0015939 [pantothenate metabolic process] GO:0016020 [membrane] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	635 aa 68.6 kDa	No	>9
SLC5A6-004 ENSP00000403851 ENST00000412471	E7EMX0 [Direct mapping] Sodium-dependent multivitamin transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	193 aa 21.1 kDa	No	5
SLC5A6-005 ENSP00000404032 ENST00000414408	E7EW41 [Direct mapping] Sodium-dependent multivitamin transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	78 aa 8.2 kDa	No	1
SLC5A6-006 ENSP00000384265 ENST00000401463	E7EW78 [Direct mapping] Sodium-dependent multivitamin transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	147 aa 16.2 kDa	No	3
SLC5A6-007 ENSP00000401347 ENST00000426119	E7ERE1 [Direct mapping] Sodium-dependent multivitamin transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	115 aa 12.3 kDa	No	3
SLC5A6-009 ENSP00000411536 ENST00000432106	E7ENG0 [Direct mapping] Sodium-dependent multivitamin transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	133 aa 14.6 kDa	No	3
SLC5A6-010 ENSP00000412115 ENST00000442731	Q9HD19 [Direct mapping] Sodium-dependent multivitamin transporter Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		27 aa 2.6 kDa	No	0
SLC5A6-011 ENSP00000399299 ENST00000430186	E7EXC0 [Direct mapping] Sodium-dependent multivitamin transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	39 aa 4 kDa	No	1
SLC5A6-012 ENSP00000402903 ENST00000428518	E7EP02 [Direct mapping] Sodium-dependent multivitamin transporter Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	59 aa 6.2 kDa	Yes	0

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