Cell atlas - ABCG5 - The Human Protein Atlas

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ABCG5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ABCG5
Gene description	ATP-binding cassette, sub-family G (WHITE), member 5
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA016514
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA016514	Hep G2	Nucleus
	HPA016514	U-2 OS	No staining
	HPA016514	U-251 MG	No staining

GENE INFORMATION
Gene name	ABCG5 (HGNC Symbol)
Synonyms	STSL
Description	ATP-binding cassette, sub-family G (WHITE), member 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p21
Chromosome location (bp)	43812472 - 43838865
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138075 (version 83.38)
Entrez gene	64240
UniProt	Q9H222 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H222
Antibodypedia	ABCG5 antibodies

PROTEIN BROWSER

ABCG5-001	ABCG5-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCG5-001 ENSP00000260645 ENST00000260645	Q9H222 [Direct mapping] ATP-binding cassette sub-family G member 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0007584 [response to nutrient] GO:0007588 [excretion] GO:0010212 [response to ionizing radiation] GO:0010949 [negative regulation of intestinal phytosterol absorption] GO:0015918 [sterol transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0016887 [ATPase activity] GO:0017127 [cholesterol transporter activity] GO:0030299 [intestinal cholesterol absorption] GO:0033344 [cholesterol efflux] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042632 [cholesterol homeostasis] GO:0043190 [ATP-binding cassette (ABC) transporter complex] GO:0043235 [receptor complex] GO:0044281 [small molecule metabolic process] GO:0045177 [apical part of cell] GO:0045796 [negative regulation of intestinal cholesterol absorption] GO:0046982 [protein heterodimerization activity] GO:0055085 [transmembrane transport] Show all	651 aa 72.5 kDa	No	6
ABCG5-002 ENSP00000384513 ENST00000405322	E7EX35 [Direct mapping] ATP-binding cassette sub-family G member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] Show all	480 aa 53.4 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.