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CYP2C9

GENERAL INFORMATION

Gene name

 CYP2C9

Gene description

 Cytochrome P450, family 2, subfamily C, polypeptide 9

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Group enriched (colon, liver, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in hepatocytes and gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA015066 , CAB016123
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, liver, small intestine)

GENE INFORMATION

Gene name

 CYP2C9 (HGNC Symbol)

Synonyms

 CYP2C10, P450IIC9

Description

 Cytochrome P450, family 2, subfamily C, polypeptide 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q23.33

Chromosome location (bp)

 94938658 - 94989390

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138109 (version 83.38)

Entrez gene

 1559

UniProt

 P11712 (UniProt - Evidence at protein level)

neXtProt

 NX_P11712

Antibodypedia

 CYP2C9 antibodies

PROTEIN BROWSER
CYP2C9-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP2C9-001
ENSP00000260682
ENST00000260682
P11712 [Direct mapping]
Cytochrome P450 2C9
S5RV20 [Target identity:100%; Query identity:100%]
Cytochrome P450 family 2 subfamily C polypeptide 9
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0008144 [drug binding]
GO:0008202 [steroid metabolic process]
GO:0008392 [arachidonic acid epoxygenase activity]
GO:0008395 [steroid hydroxylase activity]
GO:0016098 [monoterpenoid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen]
GO:0017144 [drug metabolic process]
GO:0018675 [(S)-limonene 6-monooxygenase activity]
GO:0018676 [(S)-limonene 7-monooxygenase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0019627 [urea metabolic process]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0032787 [monocarboxylic acid metabolic process]
GO:0034875 [caffeine oxidase activity]
GO:0042737 [drug catabolic process]
GO:0042738 [exogenous drug catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043603 [cellular amide metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052741 [(R)-limonene 6-monooxygenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070330 [aromatase activity]
GO:0070989 [oxidative demethylation]
GO:0097267 [omega-hydroxylase P450 pathway]
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 490 aa
55.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.