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CH25H

GENERAL INFORMATION

Gene name

 CH25H

Gene description

 Cholesterol 25-hydroxylase

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, BJ hTERT+, U-138 MG, U-87 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CH25H

Synonyms

Description

 Cholesterol 25-hydroxylase (HGNC Symbol)

Entrez gene summary

 This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q23.31

Chromosome location (bp)

 89205629 - 89207314

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138135 (version 83.38)

Entrez gene

 9023

UniProt

 O95992 (UniProt - Evidence at protein level)

neXtProt

 NX_O95992

Antibodypedia

 CH25H antibodies

PROTEIN BROWSER
CH25H-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CH25H-001
ENSP00000360918
ENST00000371852
O95992 [Direct mapping]
Cholesterol 25-hydroxylase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
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GO:0001567 [cholesterol 25-hydroxylase activity]
GO:0005506 [iron ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006699 [bile acid biosynthetic process]
GO:0008203 [cholesterol metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0008395 [steroid hydroxylase activity]
GO:0016021 [integral component of membrane]
GO:0016126 [sterol biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 272 aa
31.7 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.