Expression of KIF11 in cancer - Summary

GENERAL INFORMATION
Gene name	KIF11
Gene description	Kinesin family member 11
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues. Highest levels in subsets of cells in seminiferous duct, the gastrointestinal tract, in lymphoid tissue and bone marrow.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA006916 , HPA010568 , CAB017617
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Pancreatic cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA006916	HPA010568	CAB017617

GENE INFORMATION
Gene name	KIF11 (HGNC Symbol)
Synonyms	Eg5, HKSP, KNSL1, TRIP5
Description	Kinesin family member 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q23.33
Chromosome location (bp)	92593286 - 92655395
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138160 (version 83.38)
Entrez gene	3832
UniProt	P52732 (UniProt - Evidence at protein level)
neXtProt	NX_P52732
Antibodypedia	KIF11 antibodies

PROTEIN BROWSER

KIF11-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIF11-001 ENSP00000260731 ENST00000260731	P52732 [Direct mapping] Kinesin-like protein KIF11 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0005876 [spindle microtubule] GO:0007018 [microtubule-based movement] GO:0007051 [spindle organization] GO:0007052 [mitotic spindle organization] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007100 [mitotic centrosome separation] GO:0007596 [blood coagulation] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0008574 [ATP-dependent microtubule motor activity, plus-end-directed] GO:0016020 [membrane] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0019901 [protein kinase binding] GO:0032403 [protein complex binding] GO:0046602 [regulation of mitotic centrosome separation] GO:0051301 [cell division] GO:0090307 [mitotic spindle assembly] Show all	1056 aa 119.2 kDa	No	0