Expression of CUZD1 in cancer - Summary - The Human Protein Atlas

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CUZD1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CUZD1
Gene description	CUB and zona pellucida-like domains 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in exocrine glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA068479 , HPA068660
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA068479	HPA068660

GENE INFORMATION
Gene name	CUZD1 (HGNC Symbol)
Synonyms	ERG-1, UO-44
Description	CUB and zona pellucida-like domains 1 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q26.13
Chromosome location (bp)	122832149 - 122850793
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138161 (version 83.38)
Entrez gene	50624
UniProt	Q86UP6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q86UP6
Antibodypedia	CUZD1 antibodies

PROTEIN BROWSER

CUZD1-001	CUZD1-201	CUZD1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CUZD1-001 ENSP00000357900 ENST00000368904	Q86UP6 [Direct mapping] CUB and zona pellucida-like domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006931 [substrate-dependent cell migration, cell attachment to substrate] GO:0007049 [cell cycle] GO:0008283 [cell proliferation] GO:0016021 [integral component of membrane] GO:0030658 [transport vesicle membrane] GO:0032023 [trypsinogen activation] GO:0042588 [zymogen granule] GO:0042589 [zymogen granule membrane] GO:0051301 [cell division] Show all	607 aa 68.2 kDa	Yes	1
CUZD1-201 ENSP00000376540 ENST00000392790	Q86UP6 [Direct mapping] CUB and zona pellucida-like domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0006931 [substrate-dependent cell migration, cell attachment to substrate] GO:0007049 [cell cycle] GO:0008283 [cell proliferation] GO:0016021 [integral component of membrane] GO:0030658 [transport vesicle membrane] GO:0032023 [trypsinogen activation] GO:0042589 [zymogen granule membrane] GO:0051301 [cell division] Show all	607 aa 68.2 kDa	Yes	1
CUZD1-202 ENSP00000441590 ENST00000545804	A0A0A0MTJ4 [Direct mapping] CUB and zona pellucida-like domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	356 aa 40.2 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.