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RBP4

GENERAL INFORMATION

Gene name

 RBP4

Gene description

 Retinol binding protein 4, plasma

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (CACO-2, Hep G2, PC-3)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in renal tubules, pancreatic islets and hepatocytes with positivity in plasma.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 2 antibodies.
HPA001641 , CAB004555
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001641
CAB004555

GENE INFORMATION

Gene name

 RBP4

Synonyms

Description

 Retinol binding protein 4, plasma (HGNC Symbol)

Entrez gene summary

 This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q23.33

Chromosome location (bp)

 93591687 - 93601744

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138207 (version 83.38)

Entrez gene

 5950

UniProt

 P02753 (UniProt - Evidence at protein level)

neXtProt

 NX_P02753

Antibodypedia

 RBP4 antibodies

PROTEIN BROWSER
RBP4-001
RBP4-002
RBP4-003
RBP4-201
RBP4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBP4-001
ENSP00000360519
ENST00000371464
P02753 [Direct mapping]
Retinol-binding protein 4 Plasma retinol-binding protein(1-182) Plasma retinol-binding protein(1-181) Plasma retinol-binding protein(1-179) Plasma retinol-binding protein(1-176)
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001654 [eye development]
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006094 [gluconeogenesis]
GO:0006810 [transport]
GO:0007507 [heart development]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
GO:0030277 [maintenance of gastrointestinal epithelium]
GO:0030324 [lung development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032526 [response to retinoic acid]
GO:0034632 [retinol transporter activity]
GO:0034633 [retinol transport]
GO:0042572 [retinol metabolic process]
GO:0042593 [glucose homeostasis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048706 [embryonic skeletal system development]
GO:0048738 [cardiac muscle tissue development]
GO:0048807 [female genitalia morphogenesis]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060065 [uterus development]
GO:0060068 [vagina development]
GO:0060157 [urinary bladder development]
GO:0060347 [heart trabecula formation]
GO:0070062 [extracellular exosome]
Show all
 201 aa
23 kDa 		Yes 0
RBP4-002
ENSP00000360524
ENST00000371469
Q5VY30 [Direct mapping]
Retinol binding protein 4, plasma, isoform CRA_b; Retinol-binding protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005576 [extracellular region]
GO:0006810 [transport]
GO:0036094 [small molecule binding]
Show all
 199 aa
23 kDa 		No 0
RBP4-003
ENSP00000360522
ENST00000371467
P02753 [Direct mapping]
Retinol-binding protein 4 Plasma retinol-binding protein(1-182) Plasma retinol-binding protein(1-181) Plasma retinol-binding protein(1-179) Plasma retinol-binding protein(1-176)
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001654 [eye development]
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006094 [gluconeogenesis]
GO:0006810 [transport]
GO:0007507 [heart development]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
GO:0030277 [maintenance of gastrointestinal epithelium]
GO:0030324 [lung development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032526 [response to retinoic acid]
GO:0034632 [retinol transporter activity]
GO:0034633 [retinol transport]
GO:0042572 [retinol metabolic process]
GO:0042593 [glucose homeostasis]
GO:0043234 [protein complex]
GO:0045471 [response to ethanol]
GO:0046982 [protein heterodimerization activity]
GO:0048562 [embryonic organ morphogenesis]
GO:0048706 [embryonic skeletal system development]
GO:0048738 [cardiac muscle tissue development]
GO:0048807 [female genitalia morphogenesis]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060065 [uterus development]
GO:0060068 [vagina development]
GO:0060157 [urinary bladder development]
GO:0060347 [heart trabecula formation]
GO:0070062 [extracellular exosome]
Show all
 201 aa
23 kDa 		Yes 0
RBP4-201
ENSP00000480654
ENST00000615669
A0A0C4DGV7 [Direct mapping]
Retinol-binding protein 4
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005576 [extracellular region]
GO:0006810 [transport]
GO:0036094 [small molecule binding]
Show all
 199 aa
22.9 kDa 		Yes 0
RBP4-202
ENSP00000487033
ENST00000629763
Q5VY30 [Direct mapping]
Retinol binding protein 4, plasma, isoform CRA_b; Retinol-binding protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005576 [extracellular region]
GO:0006810 [transport]
GO:0036094 [small molecule binding]
Show all
 199 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.