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GPR87

GENERAL INFORMATION

Gene name

 GPR87

Gene description

 G protein-coupled receptor 87

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, lung cancer, urothelial cancer)
HPA (cell line):Cell line enhanced (A-431, HaCaT, hTCEpi)
HPA (normal tissue):Tissue enhanced (esophagus, skin)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, lung cancer, urothelial cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GPR87 (HGNC Symbol)

Synonyms

 GPR95

Description

 G protein-coupled receptor 87 (HGNC Symbol)

Entrez gene summary

 This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]

Chromosome

 3

Cytoband

 q25.1

Chromosome location (bp)

 151294086 - 151316952

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000138271 (version 83.38)

Entrez gene

 53836

UniProt

 Q9BY21 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9BY21

Antibodypedia

 GPR87 antibodies

PROTEIN BROWSER
GPR87-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPR87-001
ENSP00000260843
ENST00000260843
Q9BY21 [Direct mapping]
G-protein coupled receptor 87
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0008150 [biological_process]
GO:0016021 [integral component of membrane]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
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 358 aa
41.4 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.