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ANXA7

GENERAL INFORMATION

Gene name

 ANXA7

Gene description

 Annexin A7

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic and membrane expression, including expression in pancreatic islets.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB004312
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ANXA7 (HGNC Symbol)

Synonyms

 ANX7

Description

 Annexin A7 (HGNC Symbol)

Entrez gene summary

 Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q22.2

Chromosome location (bp)

 73375101 - 73414076

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138279 (version 83.38)

Entrez gene

 310

UniProt

 P20073 (UniProt - Evidence at protein level)

neXtProt

 NX_P20073

Antibodypedia

 ANXA7 antibodies

PROTEIN BROWSER
ANXA7-001
ANXA7-002
ANXA7-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANXA7-001
ENSP00000362012
ENST00000372921
P20073 [Direct mapping]
Annexin A7
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005634 [nucleus]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006914 [autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0030855 [epithelial cell differentiation]
GO:0035176 [social behavior]
GO:0042584 [chromaffin granule membrane]
GO:0044822 [poly(A) RNA binding]
GO:0048306 [calcium-dependent protein binding]
GO:0070062 [extracellular exosome]
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 466 aa
50.3 kDa 		No 0
ANXA7-002
ENSP00000362010
ENST00000372919
P20073 [Direct mapping]
Annexin A7
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006914 [autophagy]
GO:0007599 [hemostasis]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009651 [response to salt stress]
GO:0009992 [cellular water homeostasis]
GO:0010629 [negative regulation of gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0030855 [epithelial cell differentiation]
GO:0031982 [vesicle]
GO:0035176 [social behavior]
GO:0042584 [chromaffin granule membrane]
GO:0044822 [poly(A) RNA binding]
GO:0048306 [calcium-dependent protein binding]
GO:0051592 [response to calcium ion]
GO:0061025 [membrane fusion]
GO:0070062 [extracellular exosome]
Show all
 488 aa
52.7 kDa 		No 0
ANXA7-005
ENSP00000378317
ENST00000394847
B9ZVT2 [Direct mapping]
Annexin A7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
14 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.