Expression of ASCC1 in cancer - Summary - The Human Protein Atlas

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ASCC1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASCC1
Gene description	Activating signal cointegrator 1 complex subunit 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038038
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and liver cancer (unfavourable).
Pancreatic cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038038

GENE INFORMATION
Gene name	ASCC1 (HGNC Symbol)
Synonyms	ASC1p50, CGI-18, Em:AC022392.3
Description	Activating signal cointegrator 1 complex subunit 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	72096032 - 72217134
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138303 (version 83.38)
Entrez gene	51008
UniProt	Q8N9N2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N9N2
Antibodypedia	ASCC1 antibodies

PROTEIN BROWSER

ASCC1-003	ASCC1-004	ASCC1-008	ASCC1-009	ASCC1-010	ASCC1-011	ASCC1-012	ASCC1-013	ASCC1-014	ASCC1-015	ASCC1-016	ASCC1-017	ASCC1-201	ASCC1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASCC1-003 ENSP00000320810 ENST00000317168	Q8N9N2 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 A0A024QZM0 [Target identity:100%; Query identity:100%] Activating signal cointegrator 1 complex subunit 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006307 [DNA dealkylation involved in DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	357 aa 41.2 kDa	No	0
ASCC1-004 ENSP00000339404 ENST00000342444	Q8N9N2 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006307 [DNA dealkylation involved in DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	400 aa 45.5 kDa	No	0
ASCC1-008 ENSP00000320461 ENST00000317126	Q8N9N2 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 A0A024QZM0 [Target identity:100%; Query identity:100%] Activating signal cointegrator 1 complex subunit 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006307 [DNA dealkylation involved in DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	357 aa 41.2 kDa	No	0
ASCC1-009 ENSP00000431299 ENST00000486689	H0YCB3 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	292 aa 32.9 kDa	No	0
ASCC1-010 ENSP00000431573 ENST00000524829	E9PKM6 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	123 aa 14.2 kDa	No	0
ASCC1-011 ENSP00000431255 ENST00000530461	E9PM82 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	124 aa 14.2 kDa	No	0
ASCC1-012 ENSP00000432418 ENST00000527593	E9PQZ6 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	152 aa 17.7 kDa	No	0
ASCC1-013 ENSP00000431746 ENST00000533958	E9PJM2 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.7 kDa	No	0
ASCC1-014 ENSP00000431419 ENST00000526751	E9PL92 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	103 aa 12 kDa	No	0
ASCC1-015 ENSP00000435147 ENST00000525286	H0YE76 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		176 aa 20.5 kDa	No	0
ASCC1-016 ENSP00000436098 ENST00000531048	E9PR40 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 16.5 kDa	No	0
ASCC1-017 ENSP00000436409 ENST00000530394	H0YER2 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		145 aa 16.6 kDa	No	0
ASCC1-201 ENSP00000378373 ENST00000394915	Q8N9N2 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006307 [DNA dealkylation involved in DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	400 aa 45.5 kDa	No	0
ASCC1-202 ENSP00000378377 ENST00000394919	Q8N9N2 [Direct mapping] Activating signal cointegrator 1 complex subunit 1 A0A024QZM0 [Target identity:100%; Query identity:100%] Activating signal cointegrator 1 complex subunit 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006307 [DNA dealkylation involved in DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	357 aa 41.2 kDa	No	0

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The Human Protein Atlas

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