Tissue expression of MYPN - Summary - The Human Protein Atlas

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MYPN

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MYPN
Gene description	Myopalladin
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (heart muscle, skeletal muscle)
GTEx:	Group enriched (heart muscle, skeletal muscle)
FANTOM5:	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in skeletal and heart muscle.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA061494
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (heart muscle, skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (heart muscle, skeletal muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION
Gene name	MYPN (HGNC Symbol)
Synonyms	MYOP
Description	Myopalladin (HGNC Symbol)
Entrez gene summary	Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Chromosome	10
Cytoband	q21.3
Chromosome location (bp)	68106117 - 68212017
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138347 (version 83.38)
Entrez gene	84665
UniProt	Q86TC9 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TC9
Antibodypedia	MYPN antibodies

PROTEIN BROWSER

MYPN-001	MYPN-002	MYPN-003	MYPN-201	MYPN-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYPN-001 ENSP00000351790 ENST00000358913	Q86TC9 [Direct mapping] Myopalladin Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008092 [cytoskeletal protein binding] GO:0017124 [SH3 domain binding] GO:0030018 [Z disc] GO:0031674 [I band] GO:0045214 [sarcomere organization] GO:0051371 [muscle alpha-actinin binding] Show all	1320 aa 145.3 kDa	No	0
MYPN-002 ENSP00000346369 ENST00000354393	Q86TC9 [Direct mapping] Myopalladin Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008092 [cytoskeletal protein binding] GO:0017124 [SH3 domain binding] GO:0030018 [Z disc] GO:0031674 [I band] GO:0045214 [sarcomere organization] GO:0051371 [muscle alpha-actinin binding] Show all	1045 aa 114.7 kDa	No	0
MYPN-003 ENSP00000362779 ENST00000373675	Q86TC9 [Direct mapping] Myopalladin Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008092 [cytoskeletal protein binding] GO:0017124 [SH3 domain binding] GO:0030018 [Z disc] GO:0031674 [I band] GO:0045214 [sarcomere organization] GO:0051371 [muscle alpha-actinin binding] Show all	507 aa 56.2 kDa	No	0
MYPN-201 ENSP00000441668 ENST00000540630	Q86TC9 [Direct mapping] Myopalladin Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008092 [cytoskeletal protein binding] GO:0017124 [SH3 domain binding] GO:0030018 [Z disc] GO:0031674 [I band] GO:0045214 [sarcomere organization] GO:0051371 [muscle alpha-actinin binding] Show all	1320 aa 145.3 kDa	No	0
MYPN-202 ENSP00000480757 ENST00000613327	A0A087WX60 [Direct mapping] Myopalladin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1026 aa 112.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.