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STAT4

GENERAL INFORMATION

Gene name

 STAT4

Gene description

 Signal transducer and activator of transcription 4

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (Karpas-707, U-266/70, U-266/84)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression at variable levels in several tissues, most abundant in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA001860 , CAB013108
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001860
CAB013108

GENE INFORMATION

Gene name

 STAT4

Synonyms

Description

 Signal transducer and activator of transcription 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Chromosome

 2

Cytoband

Chromosome location (bp)

 191029576 - 191151596

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138378 (version 83.38)

Entrez gene

 6775

UniProt

 Q14765 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14765

Antibodypedia

 STAT4 antibodies

PROTEIN BROWSER
STAT4-001
STAT4-002
STAT4-004
STAT4-005
STAT4-006
STAT4-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAT4-001
ENSP00000351255
ENST00000358470
Q14765 [Direct mapping]
Signal transducer and activator of transcription 4
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
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 748 aa
85.9 kDa 		No 0
STAT4-002
ENSP00000376134
ENST00000392320
Q14765 [Direct mapping]
Signal transducer and activator of transcription 4
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0008283 [cell proliferation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071310 [cellular response to organic substance]
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 748 aa
85.9 kDa 		No 0
STAT4-004
ENSP00000412397
ENST00000450994
E9PBE2 [Direct mapping]
Signal transducer and activator of transcription 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 79 aa
9.5 kDa 		No 0
STAT4-005
ENSP00000414322
ENST00000432798
C9JM11 [Direct mapping]
Signal transducer and activator of transcription 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 25 aa
3.1 kDa 		No 0
STAT4-006
ENSP00000403238
ENST00000413064
C9JFG0 [Direct mapping]
Signal transducer and activator of transcription 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 97 aa
11.2 kDa 		No 0
STAT4-007
ENSP00000386288
ENST00000409995
E9PG69 [Direct mapping]
Signal transducer and activator of transcription 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 117 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.