Expression of CARF in cancer - Summary - The Human Protein Atlas

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CARF

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CARF
Gene description	Calcium responsive transcription factor
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA034557
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034557

GENE INFORMATION
Gene name	CARF (HGNC Symbol)
Synonyms	ALS2CR8, CaRF, FLJ21579, NYD-SP24
Description	Calcium responsive transcription factor (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q33.2
Chromosome location (bp)	202912214 - 202987063
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138380 (version 83.38)
Entrez gene	79800
UniProt	Q8N187 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N187
Antibodypedia	CARF antibodies

PROTEIN BROWSER

CARF-001	CARF-002	CARF-004	CARF-005	CARF-007	CARF-008	CARF-009	CARF-010	CARF-011	CARF-014	CARF-015	CARF-016	CARF-017	CARF-018	CARF-019	CARF-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CARF-001 ENSP00000384006 ENST00000402905	Q8N187 [Direct mapping] Calcium-responsive transcription factor A0A024R427 [Target identity:100%; Query identity:100%] Amyotrophic lateral sclerosis 2 (Juvenile) chromosome region, candidate 8, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0035865 [cellular response to potassium ion] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0061400 [positive regulation of transcription from RNA polymerase II promoter in response to calcium ion] GO:0071277 [cellular response to calcium ion] Show all	725 aa 80.7 kDa	No	0
CARF-002 ENSP00000414644 ENST00000438828	Q8N187 [Direct mapping] Calcium-responsive transcription factor A0A024R427 [Target identity:100%; Query identity:100%] Amyotrophic lateral sclerosis 2 (Juvenile) chromosome region, candidate 8, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0035865 [cellular response to potassium ion] GO:0061400 [positive regulation of transcription from RNA polymerase II promoter in response to calcium ion] GO:0071277 [cellular response to calcium ion] Show all	725 aa 80.7 kDa	No	0
CARF-004 ENSP00000416160 ENST00000414439	C9JI92 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		623 aa 69.4 kDa	No	0
CARF-005 ENSP00000396221 ENST00000428585	Q8N187 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0035865 [cellular response to potassium ion] GO:0061400 [positive regulation of transcription from RNA polymerase II promoter in response to calcium ion] GO:0071277 [cellular response to calcium ion] Show all	649 aa 72.4 kDa	No	0
CARF-007 ENSP00000415948 ENST00000434998	Q8N187 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0035865 [cellular response to potassium ion] GO:0061400 [positive regulation of transcription from RNA polymerase II promoter in response to calcium ion] GO:0071277 [cellular response to calcium ion] Show all	207 aa 23.2 kDa	No	0
CARF-008 ENSP00000416812 ENST00000444724	F6SXV3 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		309 aa 34.5 kDa	No	0
CARF-009 ENSP00000395276 ENST00000431787	C9JCD6 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		93 aa 10.1 kDa	No	0
CARF-010 ENSP00000391617 ENST00000414857	C9JBK9 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		131 aa 14.3 kDa	No	0
CARF-011 ENSP00000394990 ENST00000447539	C9JN29 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		80 aa 8.8 kDa	No	0
CARF-014 ENSP00000413296 ENST00000414490	C9JZ91 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		54 aa 6 kDa	No	0
CARF-015 ENSP00000394298 ENST00000430899	C9JSN4 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		21 aa 2.4 kDa	No	0
CARF-016 ENSP00000408998 ENST00000445120	C9JL40 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		38 aa 4.1 kDa	No	0
CARF-017 ENSP00000413166 ENST00000432024	C9JT99 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		73 aa 8 kDa	No	0
CARF-018 ENSP00000401918 ENST00000441569	C9JT99 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		73 aa 8 kDa	No	0
CARF-019 ENSP00000387785 ENST00000443740	C9JZI6 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all		95 aa 10.5 kDa	No	0
CARF-201 ENSP00000316224 ENST00000320443	Q8N187 [Direct mapping] Calcium-responsive transcription factor Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0035865 [cellular response to potassium ion] GO:0061400 [positive regulation of transcription from RNA polymerase II promoter in response to calcium ion] GO:0071277 [cellular response to calcium ion] Show all	649 aa 72.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.