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SSB

GENERAL INFORMATION

Gene name

 SSB

Gene description

 Sjogren syndrome antigen B (autoantigen La)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA017287 , CAB004643
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and head and neck cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA017287
CAB004643

GENE INFORMATION

Gene name

 SSB (HGNC Symbol)

Synonyms

 La, La/SSB, LARP3

Description

 Sjogren syndrome antigen B (autoantigen La) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 169791933 - 169812064

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138385 (version 83.38)

Entrez gene

 6741

UniProt

 P05455 (UniProt - Evidence at protein level)

neXtProt

 NX_P05455

Antibodypedia

 SSB antibodies

PROTEIN BROWSER
SSB-001
SSB-003
SSB-004
SSB-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSB-001
ENSP00000260956
ENST00000260956
P05455 [Direct mapping]
Lupus La protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0006400 [tRNA modification]
GO:0008334 [histone mRNA metabolic process]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
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 408 aa
46.8 kDa 		No 0
SSB-003
ENSP00000386636
ENST00000409333
P05455 [Direct mapping]
Lupus La protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006400 [tRNA modification]
GO:0008334 [histone mRNA metabolic process]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
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 408 aa
46.8 kDa 		No 0
SSB-004
ENSP00000397029
ENST00000422006
E7ERC4 [Direct mapping]
Lupus La protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006396 [RNA processing]
GO:0030529 [ribonucleoprotein complex]
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 184 aa
21.4 kDa 		No 0
SSB-005
ENSP00000396890
ENST00000417292
E9PGX9 [Direct mapping]
Lupus La protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006396 [RNA processing]
GO:0030529 [ribonucleoprotein complex]
Show all
 120 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.