Tissue expression of ABI2 - Summary - The Human Protein Atlas

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ABI2

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ABI2
Gene description	Abl-interactor 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous expression, highest in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody recognizes splice variant over expressed in CNS.
Reliability score	Supported based on 1 antibody. HPA070567
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ABI2 (HGNC Symbol)
Synonyms	ABI-2, ABI2B, AblBP3, AIP-1, argBPIA, SSH3BP2
Description	Abl-interactor 2 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q33.2
Chromosome location (bp)	203328219 - 203447723
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138443 (version 83.38)
Entrez gene	10152
UniProt	Q9NYB9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYB9
Antibodypedia	ABI2 antibodies

PROTEIN BROWSER

ABI2-001	ABI2-002	ABI2-004	ABI2-005	ABI2-006	ABI2-007	ABI2-018	ABI2-020	ABI2-201	ABI2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABI2-001 ENSP00000295851 ENST00000295851	F8WAL6 [Direct mapping] Abl interactor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005913 [cell-cell adherens junction] GO:0007611 [learning or memory] GO:0008154 [actin polymerization or depolymerization] GO:0016358 [dendrite development] GO:0016477 [cell migration] GO:0030425 [dendrite] GO:0043010 [camera-type eye development] Show all	513 aa 55.7 kDa	No	0
ABI2-002 ENSP00000261017 ENST00000261017	Q9NYB9 [Direct mapping] Abl interactor 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006928 [movement of cell or subcellular component] GO:0007010 [cytoskeleton organization] GO:0008093 [cytoskeletal adaptor activity] GO:0008154 [actin polymerization or depolymerization] GO:0016032 [viral process] GO:0016477 [cell migration] GO:0016601 [Rac protein signal transduction] GO:0017124 [SH3 domain binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019900 [kinase binding] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0031209 [SCAR complex] GO:0031625 [ubiquitin protein ligase binding] GO:0032403 [protein complex binding] GO:0048365 [Rac GTPase binding] GO:0070064 [proline-rich region binding] GO:2000601 [positive regulation of Arp2/3 complex-mediated actin nucleation] Show all	475 aa 52.4 kDa	No	0
ABI2-004 ENSP00000408898 ENST00000430418	E9PEZ7 [Direct mapping] Abl interactor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008154 [actin polymerization or depolymerization] Show all	458 aa 49.3 kDa	No	0
ABI2-005 ENSP00000391433 ENST00000424558	A0A0C4DG21 [Direct mapping] Abl interactor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008154 [actin polymerization or depolymerization] Show all	507 aa 54.8 kDa	No	0
ABI2-006 ENSP00000414703 ENST00000417864	E7EP65 [Direct mapping] Abl interactor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008154 [actin polymerization or depolymerization] Show all	486 aa 52.7 kDa	No	0
ABI2-007 ENSP00000396249 ENST00000422511	E7EW77 [Direct mapping] Abl interactor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008154 [actin polymerization or depolymerization] Show all	480 aa 52.8 kDa	No	0
ABI2-018 ENSP00000413375 ENST00000451591	H7C3Q7 [Direct mapping] Abl interactor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0008154 [actin polymerization or depolymerization] Show all	201 aa 21.5 kDa	No	0
ABI2-020 ENSP00000404352 ENST00000454023	H0Y6B5 [Direct mapping] Abl interactor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008154 [actin polymerization or depolymerization] Show all	293 aa 31.8 kDa	No	0
ABI2-201 ENSP00000261016 ENST00000261016	B7Z836 [Direct mapping] Abl interactor 2; cDNA FLJ51162, highly similar to Abl interactor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008154 [actin polymerization or depolymerization] Show all	390 aa 43.1 kDa	No	0
ABI2-202 ENSP00000261018 ENST00000261018	F8WAL6 [Direct mapping] Abl interactor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008154 [actin polymerization or depolymerization] Show all	513 aa 55.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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