Expression of SLC40A1 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC40A1
Gene description	Solute carrier family 40 (iron-regulated transporter), member 1
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CACO-2, HEL, HMC-1, T-47d)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Low cytoplasmic expression in the small intestine and bone marrow with distinct positivity in erythrocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA065634
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA065634

GENE INFORMATION
Gene name	SLC40A1 (HGNC Symbol)
Synonyms	FPN1, HFE4, IREG1, MTP1, SLC11A3
Description	Solute carrier family 40 (iron-regulated transporter), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q32.2
Chromosome location (bp)	189560579 - 189583758
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138449 (version 83.38)
Entrez gene	30061
UniProt	Q9NP59 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP59
Antibodypedia	SLC40A1 antibodies

PROTEIN BROWSER

SLC40A1-001	SLC40A1-002	SLC40A1-003	SLC40A1-004	SLC40A1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC40A1-001 ENSP00000261024 ENST00000261024	Q9NP59 [Direct mapping] Solute carrier family 40 member 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002260 [lymphocyte homeostasis] GO:0003158 [endothelium development] GO:0004872 [receptor activity] GO:0005381 [iron ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005771 [multivesicular body] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008021 [synaptic vesicle] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0017046 [peptide hormone binding] GO:0034395 [regulation of transcription from RNA polymerase II promoter in response to iron] GO:0034755 [iron ion transmembrane transport] GO:0043066 [negative regulation of apoptotic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048536 [spleen development] GO:0055072 [iron ion homeostasis] GO:0055085 [transmembrane transport] GO:0060345 [spleen trabecula formation] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0097689 [iron channel activity] GO:1903988 [ferrous iron export] Show all	571 aa 62.5 kDa	No	>9
SLC40A1-002 ENSP00000390005 ENST00000427241	E7ES28 [Direct mapping] Solute carrier family 40 member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005381 [iron ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0034755 [iron ion transmembrane transport] Show all	200 aa 21.9 kDa	No	3
SLC40A1-003 ENSP00000392730 ENST00000427419	Q4PNE6 [Direct mapping] Ferroportin 1 variant I; Ferroportin 1 variant IIA; Ferroportin 1 variant IIB; Solute carrier family 40 member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.7 kDa	No	0
SLC40A1-004 ENSP00000413549 ENST00000455320	E7EQF8 [Direct mapping] Solute carrier family 40 member 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005381 [iron ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0034755 [iron ion transmembrane transport] Show all	55 aa 6.2 kDa	No	0
SLC40A1-005 ENSP00000396134 ENST00000440626	Q4PNE6 [Direct mapping] Ferroportin 1 variant I; Ferroportin 1 variant IIA; Ferroportin 1 variant IIB; Solute carrier family 40 member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.7 kDa	No	0