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DIRC2

GENERAL INFORMATION

Gene name

 DIRC2

Gene description

 Disrupted in renal carcinoma 2

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DIRC2 (HGNC Symbol)

Synonyms

 FLJ14784, RCC4

Description

 Disrupted in renal carcinoma 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q21.1

Chromosome location (bp)

 122794795 - 122881139

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138463 (version 83.38)

Entrez gene

 84925

UniProt

 Q96SL1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96SL1

Antibodypedia

 DIRC2 antibodies

PROTEIN BROWSER
DIRC2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DIRC2-001
ENSP00000261038
ENST00000261038
Q96SL1 [Direct mapping]
Disrupted in renal carcinoma protein 2
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
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GO:0005765 [lysosomal membrane]
GO:0006810 [transport]
GO:0016021 [integral component of membrane]
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 478 aa
52.1 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.