Cell atlas - SENP7 - The Human Protein Atlas

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SENP7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SENP7
Gene description	SUMO1/sentrin specific peptidase 7
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA027259
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA027259	A-431	Nucleoplasm
	HPA027259	A-431	Cytosol
	HPA027259	U-2 OS	Nucleoplasm
	HPA027259	U-2 OS	Cytosol
	HPA027259	U-251 MG	Nucleoplasm
	HPA027259	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SENP7
Synonyms
Description	SUMO1/sentrin specific peptidase 7 (HGNC Symbol)
Entrez gene summary	The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Chromosome	3
Cytoband	q12.3
Chromosome location (bp)	101324205 - 101513241
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138468 (version 83.38)
Entrez gene	57337
UniProt	Q9BQF6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQF6
Antibodypedia	SENP7 antibodies

PROTEIN BROWSER

SENP7-001	SENP7-002	SENP7-003	SENP7-004	SENP7-005	SENP7-006	SENP7-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SENP7-001 ENSP00000377655 ENST00000394095	Q9BQF6 [Direct mapping] Sentrin-specific protease 7 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	1050 aa 119.7 kDa	No	0
SENP7-002 ENSP00000342159 ENST00000348610	Q9BQF6 [Direct mapping] Sentrin-specific protease 7 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	1017 aa 115.9 kDa	No	0
SENP7-003 ENSP00000377654 ENST00000394094	J3QT09 [Direct mapping] Sentrin-specific protease 7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	985 aa 112.5 kDa	No	0
SENP7-004 ENSP00000313624 ENST00000314261	Q9BQF6 [Direct mapping] Sentrin-specific protease 7 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	984 aa 112.2 kDa	No	0
SENP7-005 ENSP00000377651 ENST00000394091	Q9BQF6 [Direct mapping] Sentrin-specific protease 7 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	886 aa 101.2 kDa	No	0
SENP7-006 ENSP00000377647 ENST00000394085	Q9BQF6 [Direct mapping] Sentrin-specific protease 7 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	238 aa 28.1 kDa	No	0
SENP7-008 ENSP00000402977 ENST00000366089	H7C1X8 [Direct mapping] Sentrin-specific protease 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.