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GUCA1C

GENERAL INFORMATION

Gene name

 GUCA1C

Gene description

 Guanylate cyclase activator 1C

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (pancreatic cancer)
HPA (cell line):Cell line enriched (RPTEC TERT1)
HPA (normal tissue):Group enriched (heart muscle, pancreas, stomach, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in pancreas and stomach.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA041597
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA041597

GENE INFORMATION

Gene name

 GUCA1C (HGNC Symbol)

Synonyms

 GCAP3

Description

 Guanylate cyclase activator 1C (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q13.13

Chromosome location (bp)

 108907792 - 108953895

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138472 (version 83.38)

Entrez gene

 9626

UniProt

 O95843 (UniProt - Evidence at protein level)

neXtProt

 NX_O95843

Antibodypedia

 GUCA1C antibodies

PROTEIN BROWSER
GUCA1C-001
GUCA1C-002
GUCA1C-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GUCA1C-001
ENSP00000261047
ENST00000261047
O95843 [Direct mapping]
Guanylyl cyclase-activating protein 3
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
GO:0007165 [signal transduction]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0008048 [calcium sensitive guanylate cyclase activator activity]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0097381 [photoreceptor disc membrane]
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 209 aa
23.8 kDa 		No 0
GUCA1C-002
ENSP00000377535
ENST00000393963
C9JNI2 [Direct mapping]
Guanylate cyclase activator 1C, isoform CRA_b; Guanylyl cyclase-activating protein 3
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
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 196 aa
22.5 kDa 		No 0
GUCA1C-003
ENSP00000417761
ENST00000471108
C9J7M7 [Direct mapping]
Guanylyl cyclase-activating protein 3
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
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 161 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.