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COX17

GENERAL INFORMATION

Gene name

 COX17

Gene description

 COX17 cytochrome c oxidase copper chaperone

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA042226 , HPA048158
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA042226
HPA048158

GENE INFORMATION

Gene name

 COX17

Synonyms

Description

 COX17 cytochrome c oxidase copper chaperone (HGNC Symbol)

Entrez gene summary

 Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q13.33

Chromosome location (bp)

 119654513 - 119677454

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138495 (version 83.38)

Entrez gene

 10063

UniProt

 Q14061 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14061

Antibodypedia

 COX17 antibodies

PROTEIN BROWSER
COX17-001
COX17-005
COX17-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COX17-001
ENSP00000261070
ENST00000261070
Q14061 [Direct mapping]
Cytochrome c oxidase copper chaperone
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006825 [copper ion transport]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0016531 [copper chaperone activity]
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 63 aa
6.9 kDa 		No 0
COX17-005
ENSP00000417651
ENST00000484810
C9J8T6 [Direct mapping]
Cytochrome c oxidase copper chaperone; HCG2022684, isoform CRA_b
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0005758 [mitochondrial intermembrane space]
GO:0006825 [copper ion transport]
GO:0016531 [copper chaperone activity]
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 98 aa
10.9 kDa 		No 0
COX17-006
ENSP00000417923
ENST00000497116
Q14061 [Direct mapping]
Cytochrome c oxidase copper chaperone
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006825 [copper ion transport]
GO:0016531 [copper chaperone activity]
Show all
 63 aa
6.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.