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GLCE

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GENERAL INFORMATION

Gene name

 GLCE

Gene description

 Glucuronic acid epimerase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Cell line enhanced (HUVEC TERT2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA040481
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HUVEC TERT2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA040481 A-431 Mitochondria
HPA040481 U-2 OS Mitochondria
HPA040481 U-251 MG Mitochondria

GENE INFORMATION

Gene name

 GLCE (HGNC Symbol)

Synonyms

 HSEPI, KIAA0836

Description

 Glucuronic acid epimerase (HGNC Symbol)

Entrez gene summary

 Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).[supplied by OMIM, Jun 2008]

Chromosome

 15

Cytoband

 q23

Chromosome location (bp)

 69160584 - 69272217

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138604 (version 83.38)

Entrez gene

 26035

UniProt

 O94923 (UniProt - Evidence at protein level)

neXtProt

 NX_O94923

Antibodypedia

 GLCE antibodies

PROTEIN BROWSER
GLCE-001
GLCE-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLCE-001
ENSP00000454092
ENST00000559420
H0YNP1 [Direct mapping]
D-glucuronyl C5-epimerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016857 [racemase and epimerase activity, acting on carbohydrates and derivatives]
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 553 aa
62.9 kDa 		No 0
GLCE-201
ENSP00000261858
ENST00000261858
O94923 [Direct mapping]
D-glucuronyl C5-epimerase
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Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005794 [Golgi apparatus]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0015012 [heparan sulfate proteoglycan biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016857 [racemase and epimerase activity, acting on carbohydrates and derivatives]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030210 [heparin biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0047464 [heparosan-N-sulfate-glucuronate 5-epimerase activity]
GO:0050379 [UDP-glucuronate 5'-epimerase activity]
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 617 aa
70.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.