Expression of CILP in cancer - Summary - The Human Protein Atlas

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CILP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CILP
Gene description	Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (breast cancer)
HPA (cell line):	Cell line enhanced (ASC TERT1, EFO-21)
HPA (normal tissue):	Tissue enhanced (cervix, uterine, smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular and cytopalsmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA003195
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003195

GENE INFORMATION
Gene name	CILP (HGNC Symbol)
Synonyms	HsT18872
Description	Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (HGNC Symbol)
Entrez gene summary	Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	65194758 - 65211488
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138615 (version 83.38)
Entrez gene	8483
UniProt	O75339 (UniProt - Evidence at protein level)
neXtProt	NX_O75339
Antibodypedia	CILP antibodies

PROTEIN BROWSER

CILP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CILP-001 ENSP00000261883 ENST00000261883	O75339 [Direct mapping] Cartilage intermediate layer protein 1 Cartilage intermediate layer protein 1 C1 Cartilage intermediate layer protein 1 C2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0031012 [extracellular matrix] GO:0043569 [negative regulation of insulin-like growth factor receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	1184 aa 132.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.