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HCN4

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GENERAL INFORMATION

Gene name

 HCN4

Gene description

 Hyperpolarization activated cyclic nucleotide gated potassium channel 4

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (NTERA-2, U-2 OS, CACO-2, AF22)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2, U-2 OS, CACO-2, AF22)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 HCN4

Synonyms

Description

 Hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]

Chromosome

 15

Cytoband

 q24.1

Chromosome location (bp)

 73319859 - 73369264

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138622 (version 83.38)

Entrez gene

 10021

UniProt

 Q9Y3Q4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y3Q4

Antibodypedia

 HCN4 antibodies

PROTEIN BROWSER
HCN4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HCN4-001
ENSP00000261917
ENST00000261917
Q9Y3Q4 [Direct mapping]
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Cyclic Nucleotide-Regulated Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0003254 [regulation of membrane depolarization]
GO:0005216 [ion channel activity]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006936 [muscle contraction]
GO:0007268 [synaptic transmission]
GO:0008015 [blood circulation]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0031226 [intrinsic component of plasma membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0042802 [identical protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055085 [transmembrane transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0071320 [cellular response to cAMP]
GO:0071321 [cellular response to cGMP]
GO:0071805 [potassium ion transmembrane transport]
GO:0086015 [SA node cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
Show all
 1203 aa
129 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.