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Weak to moderate cytoplasmic positivity was observed in most malignant cells. Isolated cases of renal cancers and hepatocellular carcinomas exhibited strong staining. Gliomas, lymphomas, melanomas, breast and skin cancers were mainly negative.
The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]