Expression of SEMA7A in cancer - Summary

GENERAL INFORMATION
Gene name	SEMA7A
Gene description	Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Protein class	Blood group antigen proteins CD markers Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HMC-1, U-251 MG)
HPA (normal tissue):	Tissue enhanced (spleen, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic or/and membrane expression in several tissues, most abundant in testis and gastrointestinal tract

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA042273
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA042273

GENE INFORMATION
Gene name	SEMA7A (HGNC Symbol)
Synonyms	CD108, H-Sema-L, SEMAL
Description	Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Chromosome	15
Cytoband	q24.1
Chromosome location (bp)	74409289 - 74434467
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138623 (version 83.38)
Entrez gene	8482
UniProt	O75326 (UniProt - Evidence at protein level)
neXtProt	NX_O75326
Antibodypedia	SEMA7A antibodies

PROTEIN BROWSER

SEMA7A-001	SEMA7A-002	SEMA7A-005	SEMA7A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEMA7A-001 ENSP00000261918 ENST00000261918	O75326 [Direct mapping] Semaphorin-7A Show all	CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0001755 [neural crest cell migration] GO:0001934 [positive regulation of protein phosphorylation] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0021988 [olfactory lobe development] GO:0030335 [positive regulation of cell migration] GO:0031175 [neuron projection development] GO:0031225 [anchored component of membrane] GO:0038191 [neuropilin binding] GO:0045773 [positive regulation of axon extension] GO:0048675 [axon extension] GO:0050727 [regulation of inflammatory response] GO:0050919 [negative chemotaxis] GO:0060907 [positive regulation of macrophage cytokine production] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	666 aa 74.8 kDa	Yes	1
SEMA7A-002 ENSP00000438966 ENST00000543145	O75326 [Direct mapping] Semaphorin-7A Show all	CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0001755 [neural crest cell migration] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0030335 [positive regulation of cell migration] GO:0031225 [anchored component of membrane] GO:0038191 [neuropilin binding] GO:0045773 [positive regulation of axon extension] GO:0050727 [regulation of inflammatory response] GO:0050919 [negative chemotaxis] GO:0060907 [positive regulation of macrophage cytokine production] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	652 aa 73.4 kDa	Yes	1
SEMA7A-005 ENSP00000454365 ENST00000567345	H3BMF9 [Direct mapping] Semaphorin-7A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	80 aa 9.6 kDa	No	0
SEMA7A-201 ENSP00000441493 ENST00000542748	F5GYX3 [Direct mapping] Semaphorin-7A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	501 aa 57.1 kDa	No	1