Expression of NDST4 in cancer - Summary - The Human Protein Atlas

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NDST4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NDST4
Gene description	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (AF22, CACO-2, RH-30, T-47d)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, ovary)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA011129
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011129

GENE INFORMATION
Gene name	NDST4
Synonyms
Description	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q26
Chromosome location (bp)	114827763 - 115113876
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138653 (version 83.38)
Entrez gene	64579
UniProt	Q9H3R1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H3R1
Antibodypedia	NDST4 antibodies

PROTEIN BROWSER

NDST4-001	NDST4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDST4-001 ENSP00000264363 ENST00000264363	Q9H3R1 [Direct mapping] Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 Heparan sulfate N-deacetylase 4 Heparan sulfate N-sulfotransferase 4 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0008146 [sulfotransferase activity] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0015016 [[heparan sulfate]-glucosamine N-sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0019213 [deacetylase activity] GO:0030210 [heparin biosynthetic process] Show all	872 aa 100.7 kDa	No	0
NDST4-201 ENSP00000483949 ENST00000613194	Q9H3R1 [Direct mapping] Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 Heparan sulfate N-deacetylase 4 Heparan sulfate N-sulfotransferase 4 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Show all	GO:0000139 [Golgi membrane] GO:0008146 [sulfotransferase activity] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0015016 [[heparan sulfate]-glucosamine N-sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0030210 [heparin biosynthetic process] Show all	369 aa 42.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.