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PRKG2

GENERAL INFORMATION

Gene name

 PRKG2

Gene description

 Protein kinase, cGMP-dependent, type II

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (prostate, small intestine)
GTEx:Tissue enhanced (small intestine)
FANTOM5:Group enriched (colon, pituitary gland, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA007386 , CAB018739
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, pituitary gland, small intestine)

GENE INFORMATION

Gene name

 PRKG2 (HGNC Symbol)

Synonyms

 cGKII, PRKGR2

Description

 Protein kinase, cGMP-dependent, type II (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 4

Cytoband

 q21.21

Chromosome location (bp)

 81087370 - 81215117

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138669 (version 83.38)

Entrez gene

 5593

UniProt

 Q13237 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13237

Antibodypedia

 PRKG2 antibodies

PROTEIN BROWSER
PRKG2-001
PRKG2-005
PRKG2-201
PRKG2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKG2-001
ENSP00000378945
ENST00000395578
Q13237 [Direct mapping]
cGMP-dependent protein kinase 2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004692 [cGMP-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0016324 [apical plasma membrane]
GO:0030553 [cGMP binding]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
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 762 aa
87.4 kDa 		No 0
PRKG2-005
ENSP00000486129
ENST00000628926
Q13237 [Direct mapping]
cGMP-dependent protein kinase 2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004692 [cGMP-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0016324 [apical plasma membrane]
GO:0030553 [cGMP binding]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 733 aa
84.4 kDa 		No 0
PRKG2-201
ENSP00000264399
ENST00000264399
Q13237 [Direct mapping]
cGMP-dependent protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004692 [cGMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0007623 [circadian rhythm]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030553 [cGMP binding]
GO:0031965 [nuclear membrane]
GO:0032922 [circadian regulation of gene expression]
GO:0036289 [peptidyl-serine autophosphorylation]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0072661 [protein targeting to plasma membrane]
Show all
 762 aa
87.4 kDa 		No 0
PRKG2-202
ENSP00000439967
ENST00000545647
B7ZA25 [Direct mapping]
cDNA, FLJ79039, highly similar to cGMP-dependent protein kinase 2 (EC 2.7.11.12); cGMP-dependent protein kinase 2
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 342 aa
39.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.