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FGF5

GENERAL INFORMATION

Gene name

 FGF5

Gene description

 Fibroblast growth factor 5

Protein class

 Disease related genes
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (BJ, BJ hTERT+, HBF TERT88, LHCN-M2, U-138 MG)
HPA (normal tissue):Tissue enhanced (gallbladder)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 FGF5

Synonyms

Description

 Fibroblast growth factor 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q21.21

Chromosome location (bp)

 80266599 - 80336680

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138675 (version 83.38)

Entrez gene

 2250

UniProt

 P12034 (UniProt - Evidence at protein level)

neXtProt

 NX_P12034

Antibodypedia

 FGF5 antibodies

PROTEIN BROWSER
FGF5-001
FGF5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGF5-001
ENSP00000311697
ENST00000312465
P12034 [Direct mapping]
Fibroblast growth factor 5
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010001 [glial cell differentiation]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
Show all
 268 aa
29.6 kDa 		Yes 0
FGF5-002
ENSP00000398353
ENST00000456523
P12034 [Direct mapping]
Fibroblast growth factor 5
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Disease related genes
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
Show all
 123 aa
13 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.