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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FGF2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FGF2

Gene description

Fibroblast growth factor 2 (basic)

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
FDA approved drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB000125
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

FGF2 (HGNC Symbol)

Synonyms

FGFB

Description

Fibroblast growth factor 2 (basic) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q28.1

Chromosome location (bp)

122826708 - 122898236

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138685 (version 83.38)

Entrez gene

2247

UniProt

P09038 (UniProt - Evidence at protein level)

neXtProt

NX_P09038

Antibodypedia

FGF2 antibodies

PROTEIN BROWSER

FGF2-001
FGF2-002
FGF2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGF2-001
ENSP00000264498
ENST00000264498
A0A087WUF6 [Direct mapping]
Fibroblast growth factor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001759 [organ induction]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007568 [aging]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0010001 [glial cell differentiation]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0014843 [growth factor dependent regulation of skeletal muscle satellite cell proliferation]
GO:0021762 [substantia nigra development]
GO:0021940 [positive regulation of cerebellar granule cell precursor proliferation]
GO:0030324 [lung development]
GO:0042060 [wound healing]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0046668 [regulation of retinal cell programmed cell death]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048678 [response to axon injury]
GO:0048864 [stem cell development]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051726 [regulation of cell cycle]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060128 [corticotropin hormone secreting cell differentiation]
GO:0060129 [thyroid-stimulating hormone-secreting cell differentiation]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0060978 [angiogenesis involved in coronary vascular morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
288 aa
30.8 kDa
No 0
FGF2-002
ENSP00000477134
ENST00000608478
P09038 [Direct mapping]
Fibroblast growth factor 2
D9ZGF5 [Target identity:100%; Query identity:100%]
Fibroblast growth factor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006935 [chemotaxis]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0010764 [negative regulation of fibroblast migration]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014843 [growth factor dependent regulation of skeletal muscle satellite cell proliferation]
GO:0030198 [extracellular matrix organization]
GO:0030214 [hyaluronan catabolic process]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0032958 [inositol phosphate biosynthetic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042060 [wound healing]
GO:0042660 [positive regulation of cell fate specification]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048598 [embryonic morphogenesis]
GO:0050918 [positive chemotaxis]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051781 [positive regulation of cell division]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060548 [negative regulation of cell death]
GO:0060591 [chondroblast differentiation]
GO:0061045 [negative regulation of wound healing]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
GO:2000546 [positive regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
155 aa
17.3 kDa
No 0
FGF2-201
ENSP00000478620
ENST00000614010
A0A087WUF6 [Direct mapping]
Fibroblast growth factor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008083 [growth factor activity]
GO:0014843 [growth factor dependent regulation of skeletal muscle satellite cell proliferation]
Show all
288 aa
30.8 kDa
No 0

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