Cell atlas - BMP2K - The Human Protein Atlas

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BMP2K

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	BMP2K
Gene description	BMP2 inducible kinase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA026451
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026451	A-431	Nuclear speckles
	HPA026451	U-2 OS	Nuclear speckles
	HPA026451	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	BMP2K (HGNC Symbol)
Synonyms	BIKe, DKFZp434K0614
Description	BMP2 inducible kinase (HGNC Symbol)
Entrez gene summary	This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q21.21
Chromosome location (bp)	78776342 - 78916372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138756 (version 83.38)
Entrez gene	55589
UniProt	Q9NSY1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NSY1
Antibodypedia	BMP2K antibodies

PROTEIN BROWSER

BMP2K-001	BMP2K-003	BMP2K-201	BMP2K-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BMP2K-001 ENSP00000421768 ENST00000502871	Q9NSY1 [Direct mapping] BMP-2-inducible protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006468 [protein phosphorylation] Show all	662 aa 73.8 kDa	No	0
BMP2K-003 ENSP00000424668 ENST00000502613	H0Y9P1 [Direct mapping] BMP-2-inducible protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		854 aa 95.5 kDa	No	0
BMP2K-201 ENSP00000334836 ENST00000335016	Q9NSY1 [Direct mapping] BMP-2-inducible protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006468 [protein phosphorylation] GO:0019208 [phosphatase regulator activity] GO:0030500 [regulation of bone mineralization] GO:0050790 [regulation of catalytic activity] Show all	1161 aa 129.2 kDa	No	0
BMP2K-202 ENSP00000487317 ENST00000628286	K4DI97 [Direct mapping] BMP-2-inducible protein kinase; BMP2 inducible kinase, isoform CRA_d Show all	MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	355 aa 39.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.