Expression of G3BP2 in cancer - Summary - The Human Protein Atlas

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G3BP2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	G3BP2
Gene description	GTPase activating protein (SH3 domain) binding protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA018304 , HPA018425
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018304	HPA018425

GENE INFORMATION
Gene name	G3BP2 (HGNC Symbol)
Synonyms	KIAA0660
Description	GTPase activating protein (SH3 domain) binding protein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q21.1
Chromosome location (bp)	75642782 - 75724525
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138757 (version 83.38)
Entrez gene	9908
UniProt	Q9UN86 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UN86
Antibodypedia	G3BP2 antibodies

PROTEIN BROWSER

G3BP2-001	G3BP2-002	G3BP2-003	G3BP2-005	G3BP2-008	G3BP2-009	G3BP2-010	G3BP2-011	G3BP2-012	G3BP2-013	G3BP2-014	G3BP2-015	G3BP2-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
G3BP2-001 ENSP00000352738 ENST00000359707	Q9UN86 [Direct mapping] Ras GTPase-activating protein-binding protein 2 A0A024RDE5 [Target identity:100%; Query identity:100%] Ras-GTPase activating protein SH3 domain-binding protein 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006810 [transport] GO:0007253 [cytoplasmic sequestering of NF-kappaB] GO:0007265 [Ras protein signal transduction] GO:0030159 [receptor signaling complex scaffold activity] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] Show all	482 aa 54.1 kDa	No	0
G3BP2-002 ENSP00000379069 ENST00000395719	Q9UN86 [Direct mapping] Ras GTPase-activating protein-binding protein 2 A0A024RDE5 [Target identity:100%; Query identity:100%] Ras-GTPase activating protein SH3 domain-binding protein 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006810 [transport] GO:0007253 [cytoplasmic sequestering of NF-kappaB] GO:0007265 [Ras protein signal transduction] GO:0030159 [receptor signaling complex scaffold activity] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] Show all	482 aa 54.1 kDa	No	0
G3BP2-003 ENSP00000350518 ENST00000357854	Q9UN86 [Direct mapping] Ras GTPase-activating protein-binding protein 2 A0A024RDB2 [Target identity:100%; Query identity:100%] Ras-GTPase activating protein SH3 domain-binding protein 2, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006810 [transport] GO:0007253 [cytoplasmic sequestering of NF-kappaB] GO:0007265 [Ras protein signal transduction] GO:0030159 [receptor signaling complex scaffold activity] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] Show all	449 aa 50.8 kDa	No	0
G3BP2-005 ENSP00000425122 ENST00000515457	D6RE13 [Direct mapping] Ras GTPase-activating protein-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	111 aa 12.5 kDa	No	0
G3BP2-008 ENSP00000424522 ENST00000503660	D6RB17 [Direct mapping] Ras GTPase-activating protein-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006810 [transport] Show all	198 aa 22.5 kDa	No	0
G3BP2-009 ENSP00000426311 ENST00000509100	D6RGJ4 [Direct mapping] Ras GTPase-activating protein-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	125 aa 14.1 kDa	No	0
G3BP2-010 ENSP00000423960 ENST00000511146	D6RBW8 [Direct mapping] Ras GTPase-activating protein-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	116 aa 13.1 kDa	No	0
G3BP2-011 ENSP00000422614 ENST00000507252	D6RBR0 [Direct mapping] Ras GTPase-activating protein-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	102 aa 11.4 kDa	No	0
G3BP2-012 ENSP00000422748 ENST00000507745	D6RAC7 [Direct mapping] Ras GTPase-activating protein-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	141 aa 16 kDa	No	0
G3BP2-013 ENSP00000423245 ENST00000508510	D6R9A4 [Direct mapping] Ras GTPase-activating protein-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	59 aa 6.7 kDa	No	0
G3BP2-014 ENSP00000424060 ENST00000509561	D6RBM9 [Direct mapping] Ras GTPase-activating protein-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	78 aa 9 kDa	No	0
G3BP2-015 ENSP00000422830 ENST00000499709	D6R9X5 [Direct mapping] Ras GTPase-activating protein-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	56 aa 6.5 kDa	No	0
G3BP2-016 ENSP00000421621 ENST00000511868	D6REX8 [Direct mapping] Ras GTPase-activating protein-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006810 [transport] Show all	99 aa 11.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.