Cell atlas - FRAS1 - The Human Protein Atlas

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FRAS1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	FRAS1
Gene description	Fraser extracellular matrix complex subunit 1
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli (fibrillar center).
RNA cell category	Cell line enhanced (SiHa, RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA011281
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SiHa, RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli (fibrillar center).

Main location

Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011281	RH-30	Nucleoli fibrillar center
	HPA011281	SiHa	Nucleoli fibrillar center
	HPA011281	U-2 OS	Nucleoli fibrillar center

GENE INFORMATION
Gene name	FRAS1 (HGNC Symbol)
Synonyms	FLJ14927, FLJ22031, KIAA1500
Description	Fraser extracellular matrix complex subunit 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Chromosome	4
Cytoband	q21.21
Chromosome location (bp)	78057570 - 78544269
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138759 (version 83.38)
Entrez gene	80144
UniProt	Q86XX4 (UniProt - Evidence at protein level)
neXtProt	NX_Q86XX4
Antibodypedia	FRAS1 antibodies

PROTEIN BROWSER

FRAS1-001	FRAS1-004	FRAS1-005	FRAS1-007	FRAS1-008	FRAS1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FRAS1-001 ENSP00000326330 ENST00000325942	Q86XX4 [Direct mapping] Extracellular matrix protein FRAS1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0016021 [integral component of membrane] GO:0031012 [extracellular matrix] GO:0046872 [metal ion binding] GO:0061618 [sublamina densa] Show all	1976 aa 216.6 kDa	Yes	0
FRAS1-004 ENSP00000423645 ENST00000502446	H0Y9A6 [Direct mapping] Extracellular matrix protein FRAS1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	666 aa 71.4 kDa	No	0
FRAS1-005 ENSP00000423809 ENST00000508900	H0Y9C9 [Direct mapping] Extracellular matrix protein FRAS1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	652 aa 70.3 kDa	No	0
FRAS1-007 ENSP00000422221 ENST00000510944	H0Y8V2 [Direct mapping] Extracellular matrix protein FRAS1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		426 aa 47.2 kDa	No	0
FRAS1-008 ENSP00000422834 ENST00000512123	Q86XX4 [Direct mapping] Extracellular matrix protein FRAS1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002009 [morphogenesis of an epithelium] GO:0003338 [metanephros morphogenesis] GO:0005515 [protein binding] GO:0005604 [basement membrane] GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0030326 [embryonic limb morphogenesis] GO:0031012 [extracellular matrix] GO:0043588 [skin development] GO:0046872 [metal ion binding] GO:0060021 [palate development] GO:0061618 [sublamina densa] Show all	4012 aa 443.6 kDa	Yes	1
FRAS1-201 ENSP00000264899 ENST00000264899	A0A0A0MQV7 [Direct mapping] Extracellular matrix protein FRAS1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	317 aa 34.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.