Expression of SCARB2 in cancer - Summary - The Human Protein Atlas

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SCARB2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SCARB2
Gene description	Scavenger receptor class B, member 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA018014 , CAB015415
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018014	CAB015415

GENE INFORMATION
Gene name	SCARB2 (HGNC Symbol)
Synonyms	CD36L2, HLGP85, LIMP-2, LIMPII, SR-BII
Description	Scavenger receptor class B, member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Chromosome	4
Cytoband	q21.1
Chromosome location (bp)	76158737 - 76213893
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138760 (version 83.38)
Entrez gene	950
UniProt	Q14108 (UniProt - Evidence at protein level)
neXtProt	NX_Q14108
Antibodypedia	SCARB2 antibodies

PROTEIN BROWSER

SCARB2-001	SCARB2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCARB2-001 ENSP00000264896 ENST00000264896	Q14108 [Direct mapping] Lysosome membrane protein 2 A0A024RDG6 [Target identity:100%; Query identity:100%] Scavenger receptor class B, member 2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005925 [focal adhesion] GO:0006622 [protein targeting to lysosome] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0043202 [lysosomal lumen] GO:0046718 [viral entry into host cell] GO:0070062 [extracellular exosome] Show all	478 aa 54.3 kDa	Yes	1
SCARB2-002 ENSP00000399154 ENST00000452464	Q14108 [Direct mapping] Lysosome membrane protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005925 [focal adhesion] GO:0006622 [protein targeting to lysosome] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0043202 [lysosomal lumen] GO:0046718 [viral entry into host cell] GO:0070062 [extracellular exosome] Show all	335 aa 37.8 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.