Expression of CCNG2 in cancer - Summary - The Human Protein Atlas

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CCNG2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCNG2
Gene description	Cyclin G2
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA034684
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034684

GENE INFORMATION
Gene name	CCNG2
Synonyms
Description	Cyclin G2 (HGNC Symbol)
Entrez gene summary	The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q21.1
Chromosome location (bp)	77157151 - 77433388
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000138764 (version 83.38)
Entrez gene	901
UniProt	Q16589 (UniProt - Evidence at transcript level)
neXtProt	NX_Q16589
Antibodypedia	CCNG2 antibodies

PROTEIN BROWSER

CCNG2-001	CCNG2-002	CCNG2-004	CCNG2-005	CCNG2-006	CCNG2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCNG2-001 ENSP00000315743 ENST00000316355	Q16589 [Direct mapping] Cyclin-G2 A0A024RDC7 [Target identity:100%; Query identity:100%] Cyclin G2, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000075 [cell cycle checkpoint] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	344 aa 38.9 kDa	No	0
CCNG2-002 ENSP00000379002 ENST00000395640	Q16589 [Direct mapping] Cyclin-G2 A0A024RDC7 [Target identity:100%; Query identity:100%] Cyclin G2, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000075 [cell cycle checkpoint] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] Show all	344 aa 38.9 kDa	No	0
CCNG2-004 ENSP00000424665 ENST00000502280	Q16589 [Direct mapping] Cyclin-G2 A0A024RDC7 [Target identity:100%; Query identity:100%] Cyclin G2, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000075 [cell cycle checkpoint] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] Show all	344 aa 38.9 kDa	No	0
CCNG2-005 ENSP00000426476 ENST00000509972	Q16589 [Direct mapping] Cyclin-G2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000075 [cell cycle checkpoint] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] Show all	304 aa 34.5 kDa	No	0
CCNG2-006 ENSP00000426085 ENST00000512918	D6RHI3 [Direct mapping] Cyclin-G2 Show all	Predicted intracellular proteins Show all	GO:0051726 [regulation of cell cycle] Show all	160 aa 17.9 kDa	No	0
CCNG2-201 ENSP00000346379 ENST00000354403	F6WBC3 [Direct mapping] Cyclin-G2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0051726 [regulation of cell cycle] Show all	344 aa 39.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.