Expression of CDKL2 in cancer - Summary - The Human Protein Atlas

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CDKL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CDKL2
Gene description	Cyclin-dependent kinase-like 2 (CDC2-related kinase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431, RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA040672
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040672

GENE INFORMATION
Gene name	CDKL2 (HGNC Symbol)
Synonyms	KKIAMRE, P56
Description	Cyclin-dependent kinase-like 2 (CDC2-related kinase) (HGNC Symbol)
Entrez gene summary	This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q21.1
Chromosome location (bp)	75578005 - 75630716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138769 (version 83.38)
Entrez gene	8999
UniProt	Q92772 (UniProt - Evidence at protein level)
neXtProt	NX_Q92772
Antibodypedia	CDKL2 antibodies

PROTEIN BROWSER

CDKL2-001	CDKL2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDKL2-001 ENSP00000412365 ENST00000429927	Q92772 [Direct mapping] Cyclin-dependent kinase-like 2 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007548 [sex differentiation] GO:0051726 [regulation of cell cycle] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	493 aa 56 kDa	No	0
CDKL2-002 ENSP00000306340 ENST00000307465	J3KNE8 [Direct mapping] Cyclin-dependent kinase-like 2 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006468 [protein phosphorylation] Show all	570 aa 64.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.