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HADH

GENERAL INFORMATION

Gene name

 HADH

Gene description

 Hydroxyacyl-CoA dehydrogenase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA039588
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039588

GENE INFORMATION

Gene name

 HADH (HGNC Symbol)

Synonyms

 HADH1, HADHSC, SCHAD

Description

 Hydroxyacyl-CoA dehydrogenase (HGNC Symbol)

Entrez gene summary

 This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]

Chromosome

 4

Cytoband

 q25

Chromosome location (bp)

 107989714 - 108035175

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138796 (version 83.38)

Entrez gene

 3033

UniProt

 Q16836 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16836

Antibodypedia

 HADH antibodies

PROTEIN BROWSER
HADH-001
HADH-002
HADH-003
HADH-201
HADH-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HADH-001
ENSP00000312288
ENST00000309522
Q16836 [Direct mapping]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0016491 [oxidoreductase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070403 [NAD+ binding]
Show all
 314 aa
34.3 kDa 		No 0
HADH-002
ENSP00000385638
ENST00000403312
A0A0A0MSE2 [Direct mapping]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity]
GO:0006631 [fatty acid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 390 aa
42.1 kDa 		No 0
HADH-003
ENSP00000425952
ENST00000505878
E9PF18 [Direct mapping]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006631 [fatty acid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070403 [NAD+ binding]
Show all
 318 aa
35.2 kDa 		No 0
HADH-201
ENSP00000474560
ENST00000603302
Q16836 [Direct mapping]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0009725 [response to hormone]
GO:0014823 [response to activity]
GO:0016491 [oxidoreductase activity]
GO:0032868 [response to insulin]
GO:0042493 [response to drug]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046676 [negative regulation of insulin secretion]
GO:0055114 [oxidation-reduction process]
GO:0070403 [NAD+ binding]
Show all
 331 aa
36.1 kDa 		No 0
HADH-202
ENSP00000486771
ENST00000626637
E9PF18 [Direct mapping]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006631 [fatty acid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070403 [NAD+ binding]
Show all
 318 aa
35.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.