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EGF

GENERAL INFORMATION

Gene name

 EGF

Gene description

 Epidermal growth factor

Protein class

 Cancer-related genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
RAS pathway related proteins

Predicted localization

 Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (kidney)
GTEx:Tissue enhanced (kidney, pancreas, skeletal muscle)
FANTOM5:Tissue enhanced (kidney, pancreas)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney, pancreas, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney, pancreas)

GENE INFORMATION

Gene name

 EGF

Synonyms

Description

 Epidermal growth factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

 4

Cytoband

 q25

Chromosome location (bp)

 109912884 - 110012266

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138798 (version 83.38)

Entrez gene

 1950

UniProt

 P01133 (UniProt - Evidence at protein level)

neXtProt

 NX_P01133

Antibodypedia

 EGF antibodies

PROTEIN BROWSER
EGF-001
EGF-002
EGF-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EGF-001
ENSP00000265171
ENST00000265171
P01133 [Direct mapping]
Pro-epidermal growth factor Epidermal growth factor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0002576 [platelet degranulation]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0006260 [DNA replication]
GO:0007165 [signal transduction]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007262 [STAT protein import into nucleus]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021940 [positive regulation of cerebellar granule cell precursor proliferation]
GO:0030168 [platelet activation]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042327 [positive regulation of phosphorylation]
GO:0043388 [positive regulation of DNA binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051048 [negative regulation of secretion]
GO:0060749 [mammary gland alveolus development]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0090279 [regulation of calcium ion import]
GO:0090370 [negative regulation of cholesterol efflux]
GO:1900127 [positive regulation of hyaluronan biosynthetic process]
GO:2000008 [regulation of protein localization to cell surface]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 1207 aa
134 kDa 		Yes 1
EGF-002
ENSP00000424316
ENST00000509793
P01133 [Direct mapping]
Pro-epidermal growth factor Epidermal growth factor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0002576 [platelet degranulation]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0006260 [DNA replication]
GO:0007165 [signal transduction]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007262 [STAT protein import into nucleus]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0016021 [integral component of membrane]
GO:0030168 [platelet activation]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042327 [positive regulation of phosphorylation]
GO:0043388 [positive regulation of DNA binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0090279 [regulation of calcium ion import]
GO:1900127 [positive regulation of hyaluronan biosynthetic process]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 1165 aa
129.3 kDa 		Yes 1
EGF-003
ENSP00000421384
ENST00000503392
P01133 [Direct mapping]
Pro-epidermal growth factor Epidermal growth factor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0002576 [platelet degranulation]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0006260 [DNA replication]
GO:0007165 [signal transduction]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007262 [STAT protein import into nucleus]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0016021 [integral component of membrane]
GO:0030168 [platelet activation]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0031093 [platelet alpha granule lumen]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042327 [positive regulation of phosphorylation]
GO:0043388 [positive regulation of DNA binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0090279 [regulation of calcium ion import]
GO:1900127 [positive regulation of hyaluronan biosynthetic process]
GO:2000008 [regulation of protein localization to cell surface]
Show all
 1166 aa
129.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.