Cell atlas - ALG10 - The Human Protein Atlas

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ALG10

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	ALG10
Gene description	ALG10, alpha-1,2-glucosyltransferase
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA063387
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063387	RH-30	Endoplasmic reticulum
	HPA063387	SiHa	Endoplasmic reticulum
	HPA063387	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	ALG10 (HGNC Symbol)
Synonyms	ALG10A, DIE2, FLJ14751
Description	ALG10, alpha-1,2-glucosyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]
Chromosome	12
Cytoband	p11.1
Chromosome location (bp)	34022281 - 34029694
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139133 (version 83.38)
Entrez gene	84920
UniProt	Q5BKT4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5BKT4
Antibodypedia	ALG10 antibodies

PROTEIN BROWSER

ALG10-001	ALG10-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALG10-001 ENSP00000266483 ENST00000266483	Q5BKT4 [Direct mapping] Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0004583 [dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	473 aa 55.6 kDa	No	>9
ALG10-004 ENSP00000444084 ENST00000538927	F5GZZ6 [Direct mapping] Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004583 [dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0016021 [integral component of membrane] Show all	126 aa 14.6 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.