Expression of AEBP2 in cancer - Summary - The Human Protein Atlas

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AEBP2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AEBP2
Gene description	AE binding protein 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in several tissues

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA020893 , HPA022282
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020893	HPA022282

GENE INFORMATION
Gene name	AEBP2 (HGNC Symbol)
Synonyms	MGC17922
Description	AE binding protein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p12.3
Chromosome location (bp)	19404045 - 19720801
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139154 (version 83.38)
Entrez gene	121536
UniProt	Q6ZN18 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZN18
Antibodypedia	AEBP2 antibodies

PROTEIN BROWSER

AEBP2-002	AEBP2-003	AEBP2-004	AEBP2-005	AEBP2-006	AEBP2-007	AEBP2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AEBP2-002 ENSP00000381840 ENST00000398864	Q6ZN18 [Direct mapping] Zinc finger protein AEBP2 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0035098 [ESC/E(Z) complex] GO:0040029 [regulation of gene expression, epigenetic] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046872 [metal ion binding] Show all	517 aa 54.5 kDa	No	0
AEBP2-003 ENSP00000266508 ENST00000266508	Q6ZN18 [Direct mapping] Zinc finger protein AEBP2 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0035098 [ESC/E(Z) complex] GO:0040029 [regulation of gene expression, epigenetic] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046872 [metal ion binding] Show all	503 aa 52.8 kDa	No	0
AEBP2-004 ENSP00000354267 ENST00000360995	Q6ZN18 [Direct mapping] Zinc finger protein AEBP2 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0035098 [ESC/E(Z) complex] GO:0040029 [regulation of gene expression, epigenetic] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046872 [metal ion binding] Show all	301 aa 34 kDa	No	0
AEBP2-005 ENSP00000444255 ENST00000538425	F5GZR7 [Direct mapping] Zinc finger protein AEBP2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	110 aa 11.9 kDa	No	0
AEBP2-006 ENSP00000437983 ENST00000541908	G5EA50 [Direct mapping] AE binding protein 2, isoform CRA_a; Zinc finger protein AEBP2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	274 aa 30.7 kDa	No	0
AEBP2-007 ENSP00000381715 ENST00000398731	H7BYT4 [Direct mapping] Zinc finger protein AEBP2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		140 aa 16.2 kDa	No	0
AEBP2-008 ENSP00000445587 ENST00000512223	H0YH08 [Direct mapping] Zinc finger protein AEBP2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 15 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.