Expression of PRICKLE1 in cancer - Summary - The Human Protein Atlas

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PRICKLE1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRICKLE1
Gene description	Prickle homolog 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HUVEC TERT2, NTERA-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA001379
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001379

GENE INFORMATION
Gene name	PRICKLE1 (HGNC Symbol)
Synonyms	EPM1B., FLJ31937, RILP
Description	Prickle homolog 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]
Chromosome	12
Cytoband	q12
Chromosome location (bp)	42456754 - 42590355
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139174 (version 83.38)
Entrez gene	144165
UniProt	Q96MT3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96MT3
Antibodypedia	PRICKLE1 antibodies

PROTEIN BROWSER

PRICKLE1-001	PRICKLE1-002	PRICKLE1-003	PRICKLE1-004	PRICKLE1-005	PRICKLE1-006	PRICKLE1-007	PRICKLE1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRICKLE1-001 ENSP00000345064 ENST00000345127	Q96MT3 [Direct mapping] Prickle-like protein 1 A0A024R0W7 [Target identity:100%; Query identity:100%] Prickle-like 1 (Drosophila), isoform CRA_a Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001843 [neural tube closure] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006606 [protein import into nucleus] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031965 [nuclear membrane] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0035904 [aorta development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0060976 [coronary vasculature development] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000691 [negative regulation of cardiac muscle cell myoblast differentiation] Show all	831 aa 94.3 kDa	No	0
PRICKLE1-002 ENSP00000446699 ENST00000547113	F8W1Q8 [Direct mapping] Prickle-like protein 1 Q687H3 [Target identity:100%; Query identity:100%] REST/NRSF-interacting LIM domain protein Q687H4 [Target identity:100%; Query identity:100%] REST/NRSF-interacting LIM domain protein Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	110 aa 12.6 kDa	No	0
PRICKLE1-003 ENSP00000448359 ENST00000548696	Q96MT3 [Direct mapping] Prickle-like protein 1 A0A024R0W7 [Target identity:100%; Query identity:100%] Prickle-like 1 (Drosophila), isoform CRA_a Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0001843 [neural tube closure] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006606 [protein import into nucleus] GO:0008270 [zinc ion binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031965 [nuclear membrane] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000691 [negative regulation of cardiac muscle cell myoblast differentiation] Show all	831 aa 94.3 kDa	No	0
PRICKLE1-004 ENSP00000449819 ENST00000552240	Q96MT3 [Direct mapping] Prickle-like protein 1 A0A024R0W7 [Target identity:100%; Query identity:100%] Prickle-like 1 (Drosophila), isoform CRA_a Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001843 [neural tube closure] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006606 [protein import into nucleus] GO:0008270 [zinc ion binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031965 [nuclear membrane] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000691 [negative regulation of cardiac muscle cell myoblast differentiation] Show all	831 aa 94.3 kDa	No	0
PRICKLE1-005 ENSP00000398947 ENST00000445766	Q96MT3 [Direct mapping] Prickle-like protein 1 A0A024R0W7 [Target identity:100%; Query identity:100%] Prickle-like 1 (Drosophila), isoform CRA_a Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0001843 [neural tube closure] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006606 [protein import into nucleus] GO:0008270 [zinc ion binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031965 [nuclear membrane] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000691 [negative regulation of cardiac muscle cell myoblast differentiation] Show all	831 aa 94.3 kDa	No	0
PRICKLE1-006 ENSP00000447870 ENST00000552108	F8VUG8 [Direct mapping] Prickle-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	159 aa 17.8 kDa	No	0
PRICKLE1-007 ENSP00000446970 ENST00000551050	F8W1J1 [Direct mapping] Prickle-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	119 aa 13.7 kDa	No	0
PRICKLE1-201 ENSP00000401060 ENST00000455697	Q96MT3 [Direct mapping] Prickle-like protein 1 A0A024R0W7 [Target identity:100%; Query identity:100%] Prickle-like 1 (Drosophila), isoform CRA_a Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001843 [neural tube closure] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006606 [protein import into nucleus] GO:0008270 [zinc ion binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031965 [nuclear membrane] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000691 [negative regulation of cardiac muscle cell myoblast differentiation] Show all	831 aa 94.3 kDa	No	0

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