Expression of C1RL in cancer - Summary - The Human Protein Atlas

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C1RL

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C1RL
Gene description	Complement component 1, r subcomponent-like
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues with widespread extracellular positivity.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.
Reliability score	Supported based on 2 antibodies. HPA011338 , CAB026172
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011338	CAB026172

GENE INFORMATION
Gene name	C1RL (HGNC Symbol)
Synonyms	C1r-LP, C1RL1
Description	Complement component 1, r subcomponent-like (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	7089587 - 7109273
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139178 (version 83.38)
Entrez gene	51279
UniProt	Q9NZP8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZP8
Antibodypedia	C1RL antibodies

PROTEIN BROWSER

C1RL-001	C1RL-002	C1RL-003	C1RL-005	C1RL-006	C1RL-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C1RL-001 ENSP00000266542 ENST00000266542	Q9NZP8 [Direct mapping] Complement C1r subcomponent-like protein Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006958 [complement activation, classical pathway] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	487 aa 53.5 kDa	Yes	0
C1RL-002 ENSP00000442611 ENST00000545337	F5H7C8 [Direct mapping] Complement C1r subcomponent-like protein Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		187 aa 20.4 kDa	Yes	0
C1RL-003 ENSP00000441885 ENST00000544702	F5GWF3 [Direct mapping] Complement C1r subcomponent-like protein Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		314 aa 33.7 kDa	Yes	0
C1RL-005 ENSP00000437398 ENST00000543933	F5H6S5 [Direct mapping] Complement C1r subcomponent-like protein Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		192 aa 21 kDa	Yes	0
C1RL-006 ENSP00000438286 ENST00000545280	F5H2Z5 [Direct mapping] Complement C1r subcomponent-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.7 kDa	No	0
C1RL-008 ENSP00000439180 ENST00000534950	H0YFL7 [Direct mapping] Complement C1r subcomponent-like protein Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	194 aa 21 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.