Expression of PIANP in cancer - Summary - The Human Protein Atlas

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PIANP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PIANP
Gene description	PILR alpha associated neural protein
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (NTERA-2, SH-SY5Y, U-2 OS)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA010631
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010631

GENE INFORMATION
Gene name	PIANP (HGNC Symbol)
Synonyms	C12orf53, DKFZp547D2210, PANP
Description	PILR alpha associated neural protein (HGNC Symbol)
Entrez gene summary	This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Sep 2011]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6693792 - 6700800
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139200 (version 83.38)
Entrez gene	196500
UniProt	Q8IYJ0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IYJ0
Antibodypedia	PIANP antibodies

PROTEIN BROWSER

PIANP-001	PIANP-002	PIANP-003	PIANP-005	PIANP-007	PIANP-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIANP-001 ENSP00000317818 ENST00000320591	Q8IYJ0 [Direct mapping] PILR alpha-associated neural protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005912 [adherens junction] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] Show all	282 aa 30.1 kDa	Yes	1
PIANP-002 ENSP00000442157 ENST00000540656	Q8IYJ0 [Direct mapping] PILR alpha-associated neural protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005912 [adherens junction] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] Show all	282 aa 30.1 kDa	Yes	1
PIANP-003 ENSP00000443919 ENST00000534837	Q8IYJ0 [Direct mapping] PILR alpha-associated neural protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005912 [adherens junction] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] Show all	276 aa 29.4 kDa	Yes	1
PIANP-005 ENSP00000444605 ENST00000545917	F5GZA6 [Direct mapping] PILR alpha-associated neural protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		172 aa 18.2 kDa	Yes	0
PIANP-007 ENSP00000443898 ENST00000542740	F5H191 [Direct mapping] PILR alpha-associated neural protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		111 aa 12 kDa	Yes	0
PIANP-008 ENSP00000438736 ENST00000536467	F5H0N9 [Direct mapping] PILR alpha-associated neural protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		77 aa 8.4 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.