Tissue expression of LRIG3 - Summary - The Human Protein Atlas

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LRIG3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LRIG3
Gene description	Leucine-rich repeats and immunoglobulin-like domains 3
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (thyroid gland)
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membrane expression in most tissues.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA010773
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (thyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	LRIG3 (HGNC Symbol)
Synonyms	FLJ90440, KIAA3016
Description	Leucine-rich repeats and immunoglobulin-like domains 3 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q14.1
Chromosome location (bp)	58872149 - 58920522
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139263 (version 83.38)
Entrez gene	121227
UniProt	Q6UXM1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6UXM1
Antibodypedia	LRIG3 antibodies

PROTEIN BROWSER

LRIG3-001	LRIG3-002	LRIG3-006	LRIG3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRIG3-001 ENSP00000368436 ENST00000379141	Q6UXM1 [Direct mapping] Leucine-rich repeats and immunoglobulin-like domains protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] Show all	1059 aa 117.4 kDa	Yes	1
LRIG3-002 ENSP00000326759 ENST00000320743	Q6UXM1 [Direct mapping] Leucine-rich repeats and immunoglobulin-like domains protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0032474 [otolith morphogenesis] Show all	1119 aa 123.4 kDa	Yes	1
LRIG3-006 ENSP00000449109 ENST00000552267	F8VYZ5 [Direct mapping] Leucine-rich repeats and immunoglobulin-like domains protein 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	156 aa 17.6 kDa	No	0
LRIG3-008 ENSP00000449169 ENST00000550825	H0YID8 [Direct mapping] Leucine-rich repeats and immunoglobulin-like domains protein 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		163 aa 17.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.