Expression of PHLDA1 in cancer - Summary

GENERAL INFORMATION
Gene name	PHLDA1
Gene description	Pleckstrin homology-like domain, family A, member 1
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression, most abundant in salivary gland and squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA019000 , CAB016160
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA019000	CAB016160

GENE INFORMATION
Gene name	PHLDA1 (HGNC Symbol)
Synonyms	DT1P1B11, PHRIP, TDAG51
Description	Pleckstrin homology-like domain, family A, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q21.2
Chromosome location (bp)	76025447 - 76033932
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139289 (version 83.38)
Entrez gene	22822
UniProt	Q8WV24 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WV24
Antibodypedia	PHLDA1 antibodies

PROTEIN BROWSER

PHLDA1-001	PHLDA1-003	PHLDA1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHLDA1-001 ENSP00000266671 ENST00000266671	Q8WV24 [Direct mapping] Pleckstrin homology-like domain family A member 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0021879 [forebrain neuron differentiation] GO:0030659 [cytoplasmic vesicle membrane] GO:0043065 [positive regulation of apoptotic process] GO:0045210 [FasL biosynthetic process] Show all	401 aa 45 kDa	No	0
PHLDA1-003 ENSP00000473593 ENST00000602540	R4GND3 [Direct mapping] Pleckstrin homology-like domain family A member 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] Show all	260 aa 29.7 kDa	No	0
PHLDA1-201 ENSP00000480767 ENST00000619060	Q8WV24 [Direct mapping] Pleckstrin homology-like domain family A member 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0030659 [cytoplasmic vesicle membrane] Show all	401 aa 45 kDa	No	0