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TDG

GENERAL INFORMATION

Gene name

 TDG

Gene description

 Thymine DNA glycosylase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA052263
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and melanoma (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA052263

GENE INFORMATION

Gene name

 TDG

Synonyms

Description

 Thymine DNA glycosylase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 103965804 - 103988874

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139372 (version 83.38)

Entrez gene

 6996

UniProt

 Q13569 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13569

Antibodypedia

 TDG antibodies

PROTEIN BROWSER
TDG-001
TDG-003
TDG-004
TDG-007
TDG-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TDG-001
ENSP00000376611
ENST00000392872
Q13569 [Direct mapping]
G/T mismatch-specific thymine DNA glycosylase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006298 [mismatch repair]
GO:0006351 [transcription, DNA-templated]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009790 [embryo development]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0016605 [PML body]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0016925 [protein sumoylation]
GO:0019104 [DNA N-glycosylase activity]
GO:0030983 [mismatched DNA binding]
GO:0032091 [negative regulation of protein binding]
GO:0032183 [SUMO binding]
GO:0035511 [oxidative DNA demethylation]
GO:0035562 [negative regulation of chromatin binding]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042803 [protein homodimerization activity]
GO:0043566 [structure-specific DNA binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045008 [depyrimidination]
GO:0080111 [DNA demethylation]
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 410 aa
46.1 kDa 		No 0
TDG-003
ENSP00000266775
ENST00000266775
G8JL98 [Direct mapping]
G/T mismatch-specific thymine DNA glycosylase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006298 [mismatch repair]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds]
GO:0030983 [mismatched DNA binding]
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 406 aa
45.7 kDa 		No 0
TDG-004
ENSP00000445899
ENST00000544861
B4E127 [Direct mapping]
G/T mismatch-specific thymine DNA glycosylase; cDNA FLJ50939, highly similar to G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.-)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006298 [mismatch repair]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds]
GO:0030983 [mismatched DNA binding]
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 267 aa
30.2 kDa 		No 0
TDG-007
ENSP00000390167
ENST00000436021
F5H539 [Direct mapping]
G/T mismatch-specific thymine DNA glycosylase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006281 [DNA repair]
GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds]
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 138 aa
15.4 kDa 		No 0
TDG-008
ENSP00000439825
ENST00000537100
F5H0I7 [Direct mapping]
G/T mismatch-specific thymine DNA glycosylase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006298 [mismatch repair]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds]
GO:0030983 [mismatched DNA binding]
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 257 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.