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NUP58

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GENERAL INFORMATION

Gene name

 NUP58

Gene description

 Nucleoporin 58kDa

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane & mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Additional location

 In addition localized to the Plasma membrane (approved), Mitochondria (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA039360
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane & mitochondria.

Main location

 Cytosol (approved)

Additional location

 Plasma membrane (approved), Mitochondria (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA039360 A-431 Plasma membrane
Mitochondria
Cytosol
HPA039360 U-2 OS Plasma membrane
Mitochondria
Cytosol
HPA039360 U-251 MG Cytosol

GENE INFORMATION

Gene name

 NUP58 (HGNC Symbol)

Synonyms

 KIAA0410, NUP45, NUPL1

Description

 Nucleoporin 58kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q12.13

Chromosome location (bp)

 25301524 - 25349800

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139496 (version 83.38)

Entrez gene

 9818

UniProt

 Q9BVL2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BVL2

Antibodypedia

 NUP58 antibodies

PROTEIN BROWSER
NUP58-001
NUP58-004
NUP58-005
NUP58-007
NUP58-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUP58-001
ENSP00000371155
ENST00000381736
Q9BVL2 [Direct mapping]
Nucleoporin p58/p45
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005975 [carbohydrate metabolic process]
GO:0006913 [nucleocytoplasmic transport]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008139 [nuclear localization sequence binding]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0042306 [regulation of protein import into nucleus]
GO:0043234 [protein complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051028 [mRNA transport]
GO:0051260 [protein homooligomerization]
GO:0051290 [protein heterotetramerization]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0070208 [protein heterotrimerization]
GO:1900034 [regulation of cellular response to heat]
Show all
 599 aa
60.9 kDa 		No 0
NUP58-004
ENSP00000408147
ENST00000394327
Q5JRG1 [Direct mapping]
Nucleoporin p58/p45
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0006913 [nucleocytoplasmic transport]
Show all
 463 aa
49.1 kDa 		No 0
NUP58-005
ENSP00000418555
ENST00000463407
Q9BVL2 [Direct mapping]
Nucleoporin p58/p45
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 485 aa
50.2 kDa 		No 0
NUP58-007
ENSP00000371137
ENST00000381718
Q9BVL2 [Direct mapping]
Nucleoporin p58/p45
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 587 aa
59.8 kDa 		No 0
NUP58-009
ENSP00000371166
ENST00000381747
H7BYF2 [Direct mapping]
Nucleoporin p58/p45
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0006913 [nucleocytoplasmic transport]
Show all
 510 aa
53.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.