Expression of SLC46A3 in cancer - Summary - The Human Protein Atlas

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SLC46A3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC46A3
Gene description	Solute carrier family 46, member 3
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RPTEC TERT1, T-47d)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA039930
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039930

GENE INFORMATION
Gene name	SLC46A3 (HGNC Symbol)
Synonyms	DKFZp686A1775, FLJ42613
Description	Solute carrier family 46, member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q12.3
Chromosome location (bp)	28700064 - 28718970
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139508 (version 83.38)
Entrez gene	283537
UniProt	Q7Z3Q1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7Z3Q1
Antibodypedia	SLC46A3 antibodies

PROTEIN BROWSER

SLC46A3-001	SLC46A3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC46A3-001 ENSP00000370192 ENST00000380814	Q7Z3Q1 [Direct mapping] Solute carrier family 46 member 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	463 aa 51.7 kDa	No	>9
SLC46A3-003 ENSP00000266943 ENST00000266943	Q7Z3Q1 [Direct mapping] Solute carrier family 46 member 3 A0A024RDN9 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	461 aa 51.5 kDa	No	>9

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.