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SLC7A1

GENERAL INFORMATION

Gene name

 SLC7A1

Gene description

 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039721
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039721

GENE INFORMATION

Gene name

 SLC7A1 (HGNC Symbol)

Synonyms

 ATRC1, CAT-1, ERR, HCAT1, REC1L

Description

 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 13

Cytoband

 q12.3

Chromosome location (bp)

 29509410 - 29595688

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139514 (version 83.38)

Entrez gene

 6541

UniProt

 P30825 (UniProt - Evidence at protein level)

neXtProt

 NX_P30825

Antibodypedia

 SLC7A1 antibodies

PROTEIN BROWSER
SLC7A1-001
SLC7A1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC7A1-001
ENSP00000370128
ENST00000380752
P30825 [Direct mapping]
High affinity cationic amino acid transporter 1
A0A024RDQ9 [Target identity:100%; Query identity:100%]
Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 1, isoform CRA_a
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000064 [L-ornithine transmembrane transporter activity]
GO:0003333 [amino acid transmembrane transport]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015181 [arginine transmembrane transporter activity]
GO:0015189 [L-lysine transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015809 [arginine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:0097638 [L-arginine import across plasma membrane]
GO:1903352 [L-ornithine transmembrane transport]
GO:1903401 [L-lysine transmembrane transport]
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 629 aa
67.6 kDa 		No >9
SLC7A1-003
ENSP00000390092
ENST00000450494
Q5JR49 [Direct mapping]
High affinity cationic amino acid transporter 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000064 [L-ornithine transmembrane transporter activity]
GO:0003333 [amino acid transmembrane transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015181 [arginine transmembrane transporter activity]
GO:0015189 [L-lysine transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0097638 [L-arginine import across plasma membrane]
GO:1903352 [L-ornithine transmembrane transport]
GO:1903401 [L-lysine transmembrane transport]
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 121 aa
12.9 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.